[HTML][HTML] RAGE regulates oxytocin transport into the brain

Y Yamamoto, H Higashida - Communications biology, 2020 - nature.com
… important roles in maternal behaviors and social bonding. Endothelial … units, RAGE is confirmed
to be present in vascular endothelial … transport to the brain occurs in rats and it would be …

Oxytocin transported from the blood across the blood-brain barrier by receptor for advanced glycation end-products (RAGE) affects brain function related to social …

H Higashida, Y Oshima, Y Yamamoto - Peptides, 2024 - Elsevier
… in the brain vascular endothelial cells of mice fails to … the mode of transport of OT in the blood
circulation to the brain via … are elicited by brain OT increases induced by the transport of OT …

[HTML][HTML] Dual nature of RAGE in host reaction and nurturing the mother–infant bond

Y Oshima, A Harashima, S Munesue, K Kimura… - International Journal of …, 2022 - mdpi.com
… that RAGE present on brain vascular endothelial cells can bind oxytocin (OT) and transport
it from the blood to the brain, … into the brain via the BBB in RAGE-deficient mice, and the …

Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum

M Gerasimenko, O Lopatina, S Munesue… - Physiology & …, 2021 - Elsevier
… , it was shown that RAGE is a binding protein for oxytocin (OT… blood-brain barrier system
using monkey vascular endothelial … -dependent recruitment of OT is impaired, parental bonding

[HTML][HTML] Oxytocin dynamics in the body and brain regulated by the receptor for advanced glycation end-products, CD38, CD157, and nicotinamide riboside

H Higashida, K Furuhara, O Lopatina… - Frontiers in …, 2022 - frontiersin.org
… of mouse neonates, to assess this transportation, we … observed in mother mice. This neglect
leads to newborn death … and Fourth, RAGE is located in human vascular endothelial cells. …

Life events and oxytocin: Recent topics

O Yu, Y Yasuhiko - Glycative Stress Research, 2023 - jstage.jst.go.jp
… However, RAGE on the surface of cerebral vascular endothelial cells, which constitute …
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice

Oxytocin signaling pathway: from cell biology to clinical implications

M Iovino, T Messana, A Tortora, C Giusti… - … Metabolic & Immune …, 2021 - ingentaconnect.com
… of limbic olfactory area to mother-infant recognition bond, and the … In fact, mice RAGE KO
are unable to increase brain OT … of the brain centers involved in the control of arterial pressure. …

Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
… Although oxytocin has the capacity to act as a “natural … the oxytocin molecule and its receptors
and its relationship to a related hormone, vasopressin, have created challenges for its use …

Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior

N Leerach, A Harashima, S Munesue, K Kimura… - Glycoconjugate …, 2021 - Springer
… of sRAGE improved the mouse survival rate and reduced the … the BBB into the brain via the
RAGE on the brain vascular endothelial cells to … via brain function stimulated by oxytocin [11]. …

[HTML][HTML] Receptor for advanced glycation end-products and child neglect in mice: a possible link to postpartum depression

H Higashida, M Gerasimenko, Y Yamamoto - Comprehensive …, 2022 - Elsevier
… of vascular endothelial cells mainly in lungs, kidney and brain … that RAGE binds oxytocin
(OT) and transports it to the brain … of mother-child bonding, and lower adherence to infant safety …