Mechanisms ensuring endothelial junction integrity beyond VE-cadherin

CN Duong, D Vestweber - Frontiers in Physiology, 2020 - frontiersin.org
… loss of VE-cadherin and this review will discuss which other adhesive mechanisms contribute
Intercellular junctions enable endothelial cells to form multicellular structures that develop …

Molecular mechanism of VE-cadherin in regulating endothelial cell behaviour during angiogenesis

W Nan, Y He, S Wang, Y Zhang - Frontiers in Physiology, 2023 - frontiersin.org
… In addition to its adhesive function, VE-cadherin plays … show that VE-cadherin equilibrium
at intercellular junctions is … Src family kinase (SFK) interacts with the vascular endothelial

Mussel adhesive protein fused with VEcadherin extracellular domain promotes endothelial‐cell tight junctions and in vivo endothelization recovery of vascular stent

D Yang, W Yan, J Qiu, Y Huang, T Li… - Journal of …, 2020 - Wiley Online Library
adhesive protein fused with VE-cadherin extracellular domain (VE-M) specifically triggered
endothelial … stent implants coated with VE-M, we evaluated the clinical applicability of VE-M in …

[HTML][HTML] VE-cadherin endocytosis controls vascular integrity and patterning during development

CM Grimsley-Myers, RH Isaacson, CM Cadwell… - Journal of Cell …, 2020 - rupress.org
… in adhesive intercellular contacts that … cadherin-p120 complex dictates the plasticity of
endothelial junctions to govern key functions of vascular endothelial cells, including endothelial

[HTML][HTML] Adaptation of endothelial cells to shear stress under atheroprone conditions by modulating internalization of vascular endothelial cadherin and vinculin

T Zhong, Y Li, X He, Y Liu, Y Dong, H Ma… - Annals of …, 2020 - ncbi.nlm.nih.gov
… Endocytosis of VE-cadherin regulates junctional strength, … VE-cadherin leads to vascular
destabilization, intercellular gap … endothelial cell survival, and an anticoagulant, anti-adhesive

Interference with ESAM (endothelial cell-selective adhesion molecule) plus vascular endothelial-cadherin causes immediate lethality and lung-specific blood …

CN Duong, AF Nottebaum, S Butz… - … , and Vascular …, 2020 - Am Heart Assoc
… PDZ domain containing 1; VE-18) and pAb against the extracellular domain of mouse ESAM
… ESAM could support endothelial junction integrity directly by its adhesive function. Although …

Molecular mechanisms of endothelialitis in SARS-CoV-2 infection: Evidence for VE-cadherin cleavage by ACE2

L Bouillet, A Deroux, M Benmarce, C Guérin… - International Journal of …, 2023 - mdpi.com
… a monolayer of endothelial cells called vascular endothelium, … A component of endothelial
cell junctions is VE-cadherin, which … that the extracellular adhesive domain of VE-cadherin can …

Differential regulation of LPS-mediated VE-cadherin disruption in human endothelial cells and the underlying signaling pathways: a mini review

YH Chan, HH Harith, DA Israf, CL Tham - Frontiers in Cell and …, 2020 - frontiersin.org
… by the localization of the adhesive cell-cell junctional proteins … The unbound VE-cadherin is
internalized into intracellular … downstream genes such as vascular endothelial growth factor (…

[HTML][HTML] Vascular Endothelial (VE)-cadherin-mediated adherens junctions involvement in cardiovascular progenitor cell specification

V Maltabe, P Kouklis - The International Journal of Developmental …, 2021 - ijdb.ehu.eus
… They provide adhesive properties through classical cadherin receptors and the cytoplasmic
… of five repetitive homologous “cadherin domains” in their extracellular domains. Classical …

Ubiquitination of VE-cadherin regulates inflammation-induced vascular permeability in vivo

M Wilkens, L Holtermann, AK Stahl, RI Stegmeyer… - EMBO …, 2024 - embopress.org
… aspects of the cell adhesive function of VE-cadherin may be … of VE-cadherin, we detected a
higher level of intracellular VE-… - and Pyk2-dependent vascular endothelial cadherin tyrosine …