[HTML][HTML] Ion channels as therapeutic targets for viral infections: further discoveries and future perspectives
FW Charlton, HM Pearson, S Hover, JD Lippiat… - Viruses, 2020 - mdpi.com
… literature and discuss the future prospects of ion channel drugs as anti-viral agents. Firstly, …
describe how viral infections may result in ion channel dysfunction and lead to virus-induced …
describe how viral infections may result in ion channel dysfunction and lead to virus-induced …
[HTML][HTML] Assessing the potential of repurposing ion channel inhibitors to treat emerging viral diseases and the role of this host factor in virus replication
T Russell, D Gangotia, G Barry - Biomedicine & Pharmacotherapy, 2022 - Elsevier
… inhibitors could be repurposed as broad-spectrum antiviral drugs. … viruses. This review
discusses the potential of ion channels as suitable drug targets to treat diseases caused by …
discusses the potential of ion channels as suitable drug targets to treat diseases caused by …
[HTML][HTML] Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease
S Gargan, NJ Stevenson - Viruses, 2021 - mdpi.com
… , they are a prime target for the treatment of infectious viruses. This review shows that viral
ion channels have many functions and their ability to form structural channels within host …
ion channels have many functions and their ability to form structural channels within host …
Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour
… of viral life cycle hints toward their use as suited targets for therapeutic intervention against
… The activity of Kcv was found to be inhibited by the antiviral agent amantadine. Interestingly, …
… The activity of Kcv was found to be inhibited by the antiviral agent amantadine. Interestingly, …
[HTML][HTML] Modulation of adaptive immunity and viral infections by ion channels
K Bohmwald, NMS Gálvez, CA Andrade… - Frontiers in …, 2021 - frontiersin.org
… of viral proteins on the surface of infected cells, Ca 2+ channels function … In this article, we
review those ion channels and ion … , cation channels and Ca 2+ channels in the context of viral …
review those ion channels and ion … , cation channels and Ca 2+ channels in the context of viral …
[HTML][HTML] Influenza viruses: Harnessing the crucial role of the M2 ion-channel and neuraminidase toward inhibitor design
… Two major classes of anti-viral agents are … viral protein makes it a good target for antiinfluenza
drugs [114]. Evidence as to its functions has been mainly from studies of the action of drug-…
drugs [114]. Evidence as to its functions has been mainly from studies of the action of drug-…
… the effect of SARS-CoV-2 and HCV on the cellular level, and the possible role of ion channels in COVID19 progression: a review of potential targets for diagnosis and …
H Alothaid, MSK Aldughaim, K El Bakkouri… - Channels, 2020 - Taylor & Francis
… In terms of potential treatment options, several medications … Antiviral medications and
interferon-based therapies are the … of ion channels or using viral proteins as ion channels, as …
interferon-based therapies are the … of ion channels or using viral proteins as ion channels, as …
[HTML][HTML] Studying the effect of amino acid substitutions in the M2 ion channel of the influenza virus on the antiviral activity of the aminoadamantane derivative in vitro …
TM Garaev, AI Odnovorov, AA Lashkov… - Advanced …, 2021 - ncbi.nlm.nih.gov
… M2 viral protein channel is a target for antiviral therapeutic drugs… use of these drugs, the
influenza A virus, which has a high … For an in-depth study of the antiviral mechanism of the HCl*H…
influenza A virus, which has a high … For an in-depth study of the antiviral mechanism of the HCl*H…
Determination of ligand binding modes in hydrated viral ion channels to foster drug design and repositioning
BZ Zsidó, R Borzsei, V Szél… - … Information and Modeling, 2021 - ACS Publications
… The repositioning of amantadine derivatives from this influenza target … antiviral drug candidates
and many other ligands with an influence of water structure on their mechanism of action. …
and many other ligands with an influence of water structure on their mechanism of action. …
Put a cork in it: Plugging the M2 viral ion channel to sink influenza
… to human health requires antivirals that can effectively … virus (IAV) is a proton-gated,
proton-selective ion channel that is required for virus replication and is an established antiviral target. …
proton-selective ion channel that is required for virus replication and is an established antiviral target. …