… HIV-SIV chimeras, called simian–human immunodeficiency … corresponding to the CD4-binding
region on SIV were … replication compared to controls (average VLs of 10 6 –10 7 …

… -1 gp120 and anti-6×His antibodies. (C) Representative flow … Env in state 1 and CD4 binding
triggers Env transitions from … Env conformation in which the CD4 binding site is exposed. …

… virologic control. Similarly, RMs with the Mamu-A*01 allele that contributes to spontaneous
virologic control … RMs were randomized into groups (n = 6 per group). All primate studies …

… PGT121 in rhesus macaques infected with simian-human immunodeficiency virus (SHIV)
SF-… Virological control by the CD4-binding site antibody N6 in simian-human immunodeficiency …

… SHIVs that demonstrate postrebound virologic control in some RM (6, 7). The emergence of
adaptive (antibody [13, 19, … 48]) immune responses has been shown to contribute to virologic …

… stage viruses were more sensitive to neutralization by CD4-binding-site antibodies, b12 …
the two N-linked glycosylation sites are located proximal of the CD4 binding site, prompting us to …

… HIV-1 or simian/human immunodeficiency virus (SHIV) … class of bNAbs that target the CD4
binding site (CD4bs) on gp120 (… in terms of heterologous neutralization ~6 to 10 weeks after a …

… from simian immunodeficiency virus (SIV) and simian-human … captured by the anti-D7324
antibody JR-52 (6), and V2i Fabs … bound gp120 without occluding the CD4 binding site (62). …

… against SIV/simian-human immunodeficiency virus (SHIV) … coreceptor binding site in V3
and upon CD4 binding undergoes a … Antibody binding to Env was assessed by staining 4 to 6 …

… -clade neutralization shown by in vitro assays 4,5,6,7 as well as their ability to protect
monkeys in vivo from infection by simian-human chimeric virus challenge. VRC01, as one well-…