Necrotic Cell Death and Inflammasome NLRP3 Activity in Mycobacterium bovis-Infected Bovine Macrophages

O Escobar-Chavarría, A Benitez-Guzman… - Cells, 2023 - mdpi.com
Mycobacterium activate the inflammasomes NLRP3, NLRP7, … bovis AN5, an international
reference strain that exhibits … bovis have virulence mechanisms that do not require viable …

Caspase-1 inhibits IFN-β production via cleavage of cGAS during M. bovis infection

Y Liao, C Liu, J Wang, Y Song, N Sabir, T Hussain… - Veterinary …, 2021 - Elsevier
bovis can also activate caspase-1 via the AIM2 and NLRP7bovis-infected macrophages
but not in cGAMP-treated cells (… mechanism between inflammasomes activation and cGAS-…

Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages

S Subbarao, J Sanchez-Garrido, N Krishnan… - Scientific Reports, 2020 - nature.com
… This pointed to differential activation of inflammasomes by these Beijing isolates (Fig. 1D). …
the NLRP7 inflammasome as a mediator of caspase-1 activation during Mycobacterium bovis

Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis

W He, J Sun, Q Zhang, Y Li, Y Fu… - Journal of Leucocyte …, 2020 - academic.oup.com
THP-1 or primary peritoneal macrophages were seeded at … by inhibiting the activation of
NLRP3 inflammasome and … Mtb can inhibit autophagy by lipids or mycobacterial virulence

Human Amnion Epithelial Cells (AECs) Respond to the FSL-1 Lipopeptide by Engaging the NLRP7 Inflammasome

M Lavergne, C Belville, H Choltus, C Gross… - Frontiers in …, 2020 - frontiersin.org
activation of NLRP7 inflammasomes in macrophages by the … in THP-1 cells following
stimulation (94). Thus, we suggest that, like the NLRP3 inflammasomes, NLRP7 inflammasomes

ATP-binding and hydrolysis in inflammasome activation

CF Sandall, BK Ziehr, JA MacDonald - Molecules, 2020 - mdpi.com
… as inflammasome-mediated IL-1β secretion from THP-1 cells. … liberated by Mycobacterium
bovis Beijing, Mycoplasma spp., … of the NLRP7 inflammasome superstructure generated with …

[PDF][PDF] Inflammasome activation

S Lara-Reyna, EA Caseley, J Topping, F Rodrigues… - 2022 - pure-oai.bham.ac.uk
… processes underlying the activation of several inflammasomes and highlight … Virulent
Mycobacterium bovis Beijing strain activates the NLRP7 inflammasome in THP-1 macrophages

Pathophysiological implication of pattern recognition receptors in fetal membranes rupture: RAGE and NLRP inflammasome

H Choltus, M Lavergne, C De Sousa Do Outeiro… - Biomedicines, 2021 - mdpi.com
… of THP-1 cells (monocytes cell line) by Mycobacterium bovis. This activation of the
NLRP7 inflammasome … It is strongly similar to another lipopeptide, MALP-2 (Macrophage-activating

Pyroptosis and Inflammasome-Related Genes-NLRP3, NLRC4 and NLRP7 Polymorphisms Were Associated with Risk of Lung Cancer

X Jing, Y Yun, X Ji, E Yang, P Li - … and Personalized Medicine, 2023 - Taylor & Francis
… in THP-1 macrophages in response to M. … of NLRP7, we hypothesized that rs775882 may
exert an effect on risk of the disease through disturbing the activation of NLRP7 inflammasome

An update on CARD only proteins (COPs) and PYD only proteins (POPs) as inflammasome regulators

S Devi, C Stehlik, A Dorfleutner - International journal of molecular …, 2020 - mdpi.com
… of an inflammasome, including NLRP2, NLRP6, NLRP7, … mouse macrophages was also
able to impair inflammasome … , inflammasome inhibition was detected in monocytic THP-1