… of neuropathic pain (2, 6–14), the peripheral nervous system … ion channels associated with
neuropathic pain, clinical results with K + channel activators and novel Na + or Ca 2+ channel …

… activity via the voltage-gated sodium channels, particularly through Na v 1.7, Na … pain using
the non-selective sodium channel blocker lidocaine by effectively blocking the NaV channels …

… new, efficacious drugs. Evidence points toward voltage-gated sodium channels as a key
target for novel … in myelinated fibers of the CNS and the PNS. It is also present in the small …

… antagonist will produce a new class of analgesic drug. … the CNS and peripheral nervous
system makes them poor … of the major drivers of neuropathic pain. Despite some claims …

… (DRG) neurons, whose excitability is driven by voltage-gated sodium (Na V ) channels.
Three Na V … Status of peripheral sodium channel blockers for non-addictive pain treatment. …

… at developing new treatment strategies to treat neuropathic pain with better … therapeutic drugs,
we reviewed new preclinical and clinical targets currently … Voltage-Gated sodium channels …

… (NP) were developed in rodents with a total lesion of the sciatic nerve. Later, other … novel
mechanisms that contribute to persistent pain conditions in NP. Objective assessment of pain in …

… neurons, suggesting that oxaliplatin preferentially acts on certain types of voltage-gated
sodium channel isoforms expressed mainly in the peripheral nervous system. Sittl et al. [32] also …

… the development of new therapeutic strategies for neuropathic pain. … The lesions in the central
or peripheral nervous system … Therefore, targets on voltage-gated sodium channels could …

… but also provides the new insights into HSV-1 induced pain. … therapeutic target to treat
inflammatory or neuropathic pain … system (CNS) or peripheral nervous system (PNS), Nav1.4 is …