… or exogenous ligands or effectors affect Hb allostery. … Hb \( \zeta_{2} \beta_{2}^{s} \) inhibits
polymerization of deoxygenated … chloride ions are found in the larger T structure central water …

… effect of solvated O 2 supports our earlier observation for the allosteric regulation of hemoglobin…
that such ions are essential and water molecules around the ions may be unimportant for …

… allosteric effectors can be used to decrease polymerization by … are tied together through
water-mediated hydrogen bonds. … to determine the effect of the synthesized allosteric effectors on …

… the middle of the central water cavity of liganded Hb structure (… of fetal hemoglobin (HbF) to
prevent polymerization of HbS … effects are directly mitigated by inhibiting HbS polymerization. …

… We show that control of polymerization by oxygen at … cause the loss of potassium ions and
water that result in red cells … did not include the effect of total hemoglobin concentration on the …

… β subunit of hemoglobin (Hb), promoting Hb polymerization and … α chains and largely driving
the allosteric transition, and a … molecules and an additional 214 sodium and chloride ions, …

… level interactions in the HbS polymer that provides its stability, … (2,3-DPG), an allosteric
regulator. p 50 of HbA in presence of … caused by the loss of K + , Cl − ions and water. Two major …

… CO 2 also exerts an indirect allosteric effect on Hb–O 2 … , CO 2 reacts with water to form
bicarbonate ions and protons, a … ions or organic phosphates to separate the allosteric effects of …

… oxygen affinity and prevent the polymerization of HbS. In 2019… effects on normal hemoglobin.
Thus, the further research of … to relax the hydrogens, water molecules, and salt ions. Then, …

… various mechanisms that include allosteric effects, coordination … with 50 % polymerized bovine
hemoglobin; methemoglobin … cells change their shape and ion channels in the membrane …