… CO 2 reacts with water to form bicarbonate ions and protons, … ions or organic phosphates
to separate the allosteric effects of … We provide a detailed functional analysis on the allosteric …

… Traditionally, the allosteric mechanism has been explained … initial ion positions in each
condition, we carried out an ion … 2 -liganded state changes, water effects) are required for this …

… oxygen affinity and prevent the polymerization of HbS. In 2019… effects on normal hemoglobin.
Thus, the further research of … to relax the hydrogens, water molecules, and salt ions. Then, …

… dodecahedral box solvated with water. Randomly chosen … the intense effect of oxygenation
on sickle hemoglobin fibrils. … and polymerization of recombinant hemoglobin report that …

… level interactions in the HbS polymer that provides its stability, … (2,3-DPG), an allosteric
regulator. p 50 of HbA in presence of … caused by the loss of K + , Cl − ions and water. Two major …

… Since milli-Q water is confirmed to contain extremely low … In this experiment, no additional
ions or surfactants were added to … Thus, NPs have no effect on environmental changes around …

… hemoglobins or hemolysates, in the presence of allosteric … the average degree of
polymerization of the macromolecule in … for mammalian hemoglobins are: hydrogen ions, chloride …

… various mechanisms that include allosteric effects, coordination … with 50 % polymerized bovine
hemoglobin; methemoglobin … cells change their shape and ion channels in the membrane …

… inhibitive effects to polymerization in … allosteric nature of hemoglobin was developed by
Monod, Wyman and Changeux (MWC).The MWC model proposes that the subunits of allosteric …

… Characterizing allostery in multiliganded systems (combinatorial allostery) represents a …
to fully describe allosteric effects in multiply-liganded states. Here, we describe combinatorial …