… To identify the critical mutations of affecting radiotherapy benefit in PC, whole exome
sequencing was utilized in six pancreatic ductal adenocarcinoma (PDAC) patients (three with a …

… lesions and invasive pancreatic cancers, we performed whole exome sequencing of 39 …
and associated invasive cancers, suggesting that global genomic instability may be important as …

… ; Figure S2: Mutational signature analysis of whole exome sequencing data from the whole
population of pancreatic tumors; Figure S3: Analysis of homologous repair aberrations, SNV …

… (ACC) consists of 1% to 2% of adult pancreatic neoplasms and has … poor understanding of
the molecular characteristics of ACC. … whole-exome sequencing and a sample identification …

… cancers hampered identification of rare driver genes. Subsequent efforts relied on whole-exome
sequencing … genes and a range of genomic instability in PDAC, with the most unstable …

… and pancreatic cancer. To determine the relevance of BRCA1/2 alterations across cancer
types, we evaluated the pan-cancer … setting using whole-exome or whole-genome sequencing; …

… with molecular-barcoded whole-exome sequencing, we … previously used in the analysis of
genomic instability (17). A … dataset of patients with pancreatic cancer. This finding is in line with …

… leads to aggressive tumors characterized by enhanced early … genomic instability in tumors.
In studies from the International … ) frequencies derived from whole exome sequencing (WES) …

… pancreatic tumor samples without matched non-tumor tissues was investigated by …
Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability …

… genomic instability in metastatic pancreatic cancer. Campbell et al. reported that an instability
pattern in pancreatic metastatic cancer … analysis, we can better characterise the genetics of …