… revealed CDKN2A copy-number loss as the most frequent alteration of bladder tumors, …
presents the REMARK diagram of our clinical study, while detailed clinicopathological 153 …

… Our analysis revealed that several genes in NMIBC did not … The clinicopathological
characteristics of enrolled patients were … As for the comparison of somatic mutations between male …

… vulnerabilities in bladder tumors with CDKN1A mutations, we … mutations are the most
common somatic lesion in bladder … reveal a high prevalence of inactivating truncating mutations …

… Clinicopathologic Characteristics of the Samples … All genomic regions that are overrepresented
(indicative of somatic … In this study, the low-coverage whole-genome sequencing method …

… to distinguish from tumour mutations. Closer investigation … Chapter 3: Identification of
somatic features of response and … -invasive bladder tumours have undergone a whole genome …

… Somatic mutations that affect cellular pathways pertinent to … derived CDKN1A mutations in
bladder cancer cell lines, we targeted three CRISPR sgRNAs along the length of the CDKN1A …

… Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and
clinicopathological associations with mutation burden. Nat Commun. (2014) ;5: . …

… In line with the clinicopathological feature, NPS3 patients … cells but nearly undetectable in
most somatic cells due primarily to … , CDKN2B, RB1 and CDKN1A are commonly inactivated by …

… Sequencing methods include whole genome sequencing, … upper urinary tract urothelial
carcinoma and bladder cancer. … [32] established a clinicopathological classi er of KNN51 …

… specimens to identify nonsynonymous mutations/exome. The … Cancer Genome Atlas cohort,
analysis of focal somatic copy number alterations by SNP-array and low pass whole genome …