Proteome-wide analysis using SOMAscan identifies and validates chitinase-3-like protein 1 as a risk and disease marker of delirium among older adults undergoing …

SM Vasunilashorn, ST Dillon, NY Chan… - The Journals of …, 2022 - academic.oup.com
… Our identification of CHI3L1/YKL-40 in postoperative delirium parallels reports of CHI3L1/YKL-40
in diseases that are characterized by tissue remodeling and/or inflammation. CHI3L1/…

[PDF][PDF] Chitinase-3 Like-Protein-1 (YKL-40) Promotes Anorectal Mucosal Melanoma Progression via the PI3K-AKT Signaling Pathway

Y Li - Ann Clin Med Case Rep, 2023 - acmcasereport.org
… pathophysiology including inflammation, cell proliferation and tissue remodeling [12-14].
YKL-40 is a … YKL-40 activates a cascade of MAP kinases (MAP kinases) and PI-3K signaling in …

Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model

L Wang, A Bao, Y Zheng, A Ma, Y Wu, H Shang… - Gene Therapy, 2021 - nature.com
… , also called human cartilage gp-39 or chitinase-3 like 1 protein (CHI3L1), is a chitinase-like
inflammation and remodeling. The present study has demonstrated that down-regulation of …

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer's disease

M Moreno-Rodriguez, SE Perez, M Nadeem… - Journal of …, 2020 - Springer
… , particularly chitinase 3-like 1 (CHI3L1, YKL-40, or HC gp-39… in pro-inflammatory and
pro-angiogenic tissue remodeling in … Functionally, CD44 and chitinase-like proteins are implicated …

Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study

F Brosseron, A Maass, L Kleineidam… - Alzheimer's research & …, 2023 - Springer
inflammatory cytokines, chemokines, or complement factors in AD. Although meta-analyses
attest a moderate elevation of pro-inflammatory … , we investigated inflammatory protein serum …

The inflammatory biomarker YKL-40 is elevated in the serum, but not the sputum, of E-cigarette users

MF Perez, NC Atuegwu, EM Mortensen… - Experimental lung …, 2020 - Taylor & Francis
… The chitinase-like protein YKL-40 has shown promise as a biomarker of lung disease
characterized by inflammation, lung parenchyma remodeling and fibrosis.Citation 18–20 …

Titanium induces proinflammatory and tissue-destructive responses in primary human macrophages

A Gudima, D Hesselbarth, G Li, V Riabov… - Journal of Leukocyte …, 2024 - academic.oup.com
Intersecting points represent the number of genes … of CHI3L1 (YKL-40), a chitinase-like
protein that can induce … -associated factor, and MMP7, as major tissue remodeling factor …

THE ROLE OF CHI3L1 IN BREAST CANCER¿ A DRIVER OF IMMUNOSUPPRESSION ON THE ROADOF TUMOR PROGRESSION¿

A Darwich - 2020 - air.unimi.it
… We identified Chitinase 3 like-1 protein (CHI3L1/YKL-40) as … , a hallmark of YKL-40 and
other chitinase like-proteins is the … be associated with tissue remodeling and repair according to …

Macrophage and Chondrocyte Phenotypes in Inflammation

A Pemmari - 2022 - trepo.tuni.fi
… Part I of this study concerns the effects of mitogen-activated protein kinase (MAPK)
phosphatase 1 (MKP-1), which has previously been shown to attenuate inflammation, on M2 …

Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in …

R Salembier, C De Haes, J Bellemans… - Breast Cancer …, 2024 - Springer
… in immunosuppression under inflammatory conditions such as … for studying
macrophage-mediated lymphatic remodeling. … 3-like 1/YKL-40 Quantikine enzyme-linked …