Aberrant protein glycosylation in cancer: implications in targeted therapy

JG Rodrigues, HO Duarte, CA Reis… - Biochemical Society …, 2021 - portlandpress.com
… Furthermore, such aberrant glycan structures play key roles in the acquisition of molecular
… anti-cancer targeted agents. In this review, we highlight the impact of glycosylation in cancer

Altered glycosylation in cancer: A promising target for biomarkers and therapeutics

D Thomas, AK Rathinavel, P Radhakrishnan - … (BBA)-Reviews on Cancer, 2021 - Elsevier
cancerglycosylation machinery is associated with cancer progression and metastasis. We
also provide insights into the influence of aberrant glycosylation in the development of cancer

[HTML][HTML] Aberrant protein glycosylation: Implications on diagnosis and Immunotherapy

R Bangarh, C Khatana, S Kaur, A Sharma… - Biotechnology …, 2023 - Elsevier
… receptors lead to many diseases, including cancer. These alterations give rise to micro- …
glycosylation and its regulatory function in autoimmunity and aberrant glycosylation in cancer. …

Abnormal glycosylation of cancer stem cells and targeting strategies

T Khan, H Cabral - Frontiers in oncology, 2021 - frontiersin.org
… The importance of altered glycosylation of tumor in disease progression has been well
documented (14). In the following sections, we focused on the aberrant glycosylation in CSC …

Aberrant sialylation in ovarian cancers

WL Lee, PH Wang - Journal of the Chinese Medical Association, 2020 - journals.lww.com
… but dramatically and markedly decreased in colon cancer. … to the aberrant sialylation-related
diseases, such as cancers will … the altered sialylation on epithelial ovarian cancers (EOCs). …

[HTML][HTML] Lung cancer molecular mutations and abnormal glycosylation as biomarkers for early diagnosis

S Yang, J Xia, Z Yang, M Xu, S Li - Cancer Treatment and Research …, 2021 - Elsevier
glycosylation is considered a hallmark of cancer and other diseases. A large number of
studies have shown that aberrant glycosylation is … In fact, it has been found that glycosylation

Glycosylation in cancer: its application as a biomarker and recent advances of analytical techniques

Y Haga, K Ueda - Glycoconjugate Journal, 2022 - Springer
… Altered glycosylation as a hallmark of cancer Aberrant glycosylation in human cancer was
initially suggested by Hakomori and his colleagues as evidenced by the marked accumulation …

Aberrant glycosylation as immune therapeutic targets for solid tumors

Y Matsumoto, T Ju - Cancers, 2023 - mdpi.com
… Strategies for targeting the aberrant glycans are currently … aberrant glycosylation as
therapeutic targets for solid tumors. … The altered glycosylation with unique structures in cancers, …

Aberrant sialylation in cancer: therapeutic opportunities

J Munkley - Cancers, 2022 - mdpi.com
Cancer cells have a different ‘glycan coat’ to healthy cells and aberrant glycosylation is a
universal feature of cancer cells linked to all of the cancer hallmarks. This means glycans hold …

Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression

M de-Souza-Ferreira, ÉE Ferreira… - Cellular Oncology, 2023 - Springer
Background Changes in protein glycosylation are widely observed in tumor cells. N-glycan
branching through adding β1,6-linked N-acetylglucosamine (β1,6-GlcNAc) to an α1,6-linked …