… signaling to cause tubular epithelial cell death and AKI via the G1 cell cycle arrest mechanism.
This is further confirmed in Smad3 knockout mice and cells in which deletion of Smad3 …

… Their effects result in G1 cell-cycle arrest for a short period to avoid cell division when cells
… Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. …

… We demonstrate that MSC-exos ameliorate ischemic AKI and promote tubular repair by
targeting the cell cycle arrest and apoptosis of TECs through miR-125b-5p/p53 pathway. This …

… Acute kidney injury (AKI) is characterized by a sudden decrease in renal function, which …
The proliferation cell cycle was measured by the Cell Cycle and Apoptosis Analysis Kit. All …

… cell cycle. If the energy is deemed insufficient, the cell will proceed into cell cycle arrest to
avoid energy failure … Any delay or inadequacy of this rescue action finally results in cell death. …

… , death and acute kidney injury (AKI), which … cell cycle arrest of tubular cells after acute
damage could provide important protection by preventing the division of potentially damaged cells …

… 2 /M cell cycle arrest, distinct from other reports of maladaptive PTCs following kidney injury.
Fate… To examine the cell cycle state of PTCs in this study, we performed gene set enrichment …

… ), the so-called cell cycle arrest biomarkers, showed a superior … cell cycle arrest biomarkers,
to aid critical care physicians and nephrologists in the early prediction of acute kidney injury …

… S phase of the cell cycle, thereby preventing cell-cycle progression and cancer growth. …
cycle arrest through CDK4/6 inhibition has been found to protect proximal tubular epithelial cells …

… that these cell cycle markers do not faithfully indicate cell proliferation but rather cell cycle entry
to … with a G2/M cell cycle arrest 43 . Consistently, Gerhardt et al. observed no sign of G2/M …