… elevated MMP9 levels in AD brains and the reduced ability of apoE4 to modulate MMP9 …
to investigate the therapeutic value of modulating MMP9 activity in E4FAD transgenic animals, …

… modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds
for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer’s disease. …

… In conclusion, our findings suggest that sex modulates the influence of MMP-9 on AD-related
pathology and cognitive impairment and may crucially inform our understanding of the …

… for the design of therapeutic agents that modulate their activities. … of MMP-9, which could
occasionally behave as a α-secretase-like enzyme. However, chronic overexpression of MMP-9 …

… 9 (MMP9) and viral coat proteins cause neuronal damage by modulating intracellular signalling
… The formation of Aβ plaques in the nerve tissue is a hallmark of Alzheimer's disease. The …

… (Aβ), contributing to the onset of Alzheimer's disease (AD). While altered MMP … MMP9
modulation improves specific neurobehavioral deficits in a mouse model of Alzheimer’s disease…

… of MMP9, where our simulation indicated an increase in MMP9 … The expression of MMP9
is also regulated by HMGB1 … Aβ at a much faster rate than MMP9, providing a route for Aβ …

… result in the long-term modulation of the MMPs/TIMPs system … the plasmatic levels of MMP1,
MMP9, and MMP10 and of the … rTMS on the modulation of neuroinflammatory mechanisms …

… that have the potential to modulate ECM deposition and turnover in vivo. … to modulation
PNN integrity. In accordance with this hypothesis, our lab has previously shown that MMP-9 …

… the 5xFAD mouse model of Alzheimer's disease (AD) reduces … the possibility that such
modulations occur in young neural … the levels of MMP-2 and MMP-9, also known as gelatinase A …