[HTML][HTML] The PKR/P38/RIPK1 signaling pathway as a therapeutic target in Alzheimer's disease

J Hugon, C Paquet - International Journal of Molecular Sciences, 2021 - mdpi.com
p38 MAPK is implicated in many pathological processes in the pathogenesis of AD [47].
Numerous studies have revealed that p38 MAPK … mouse model of Alzheimer disease. J. Biol. …

[HTML][HTML] SkQ1 suppresses the p38 MAPK signaling pathway involved in Alzheimer's disease-like pathology in OXYS rats

NA Muraleva, NA Stefanova, NG Kolosova - Antioxidants, 2020 - mdpi.com
… As a target protein phosphorylated by components of the p38 MAPK pathway, we examined
the expression of molecular chaperone CryaB and the level of its phosphorylation at the …

[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
… of Alzheimer’s disease (AD), several studies have shown that the p38 MAPK cascade is …
In recent decades, many reports have shown that the p38 MAPK signaling pathway plays …

Metabolic reprogramming of microglia enhances proinflammatory cytokine release through EphA2/p38 MAPK pathway in Alzheimer's disease

X Ma, Y Zhang, D Gou, J Ma, J Du… - … of Alzheimer's …, 2022 - content.iospress.com
… This study demonstrated that EphA2/p38 MAPK pathway is involved the release of
proinflammatory cytokines in microglia induced by Aβ 1-42 in AD, which is accompanied by …

[HTML][HTML] When good kinases go rogue: GSK3, p38 MAPK and CDKs as therapeutic targets for Alzheimer's and Huntington's disease

SR D'Mello - International Journal of Molecular Sciences, 2021 - mdpi.com
… indicate cross-talk between the cell cycle machinery and signaling by GSK3 and p38 MAPK.
… As described in this review, kinases including GSK3, p38 MAPK and CDKs affect disease

… memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways

EA Mohamed, HI Ahmed, HS Zaky, AM Badr - Journal of …, 2021 - Elsevier
… Neuroinflammation and oxidative stress have been the predominant pathogenic events
in Alzheimer's disease (AD) which is one of the most common neurodegenerative diseases. …

[HTML][HTML] miR-146a aggravates cognitive impairment and Alzheimer disease-like pathology by triggering oxidative stress through MAPK signaling

H Zhan-Qiang, Q Hai-Hua, Z Chi, W Miao, Z Cui… - Neurologia, 2023 - Elsevier
… Moreover, the p38 MAPK signaling pathway and ROS production were activated upon …
the levels of APP, ROS, and p-p38 MAPK. A similar phenomenon was also observed in the …

P38K and JNK pathways are induced by amyloid-β in astrocyte: Implication of MAPK pathways in astrogliosis in Alzheimer's disease

P Saha, S Guha, SC Biswas - Molecular and Cellular Neuroscience, 2020 - Elsevier
… To further validate the implication of p38K pathway in Aβ-induced astrocyte … p38, is
phosphorylated upon Aβ treatment. Taken together, our study indicates that p38K and JNK pathways

Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR

KW Chang, HF Zong, MY Rizvi, KG Ma, W Zhai… - … of Learning and …, 2020 - Elsevier
… Thus, short-term object recognition memory was spared in Aβ-injected mice, and it was
restored by the α7nAChR agonist, p38 MAPK inhibitor, ERK MAPK inhibitor and JNK MAPK

The p38 MAPK inhibitors and their role in inflammatory diseases

TR Machado, TR Machado, PG Pascutti - ChemistrySelect, 2021 - Wiley Online Library
… roles of p38 MAPK in the development of chronic inflammation, autoimmunity, Alzheimer's
disease, … p38 MAPK signaling ends through dephosphorylation of both threonine and tyrosine …