[HTML][HTML] The PKR/P38/RIPK1 signaling pathway as a therapeutic target in Alzheimer's disease
J Hugon, C Paquet - International Journal of Molecular Sciences, 2021 - mdpi.com
… p38 MAPK is implicated in many pathological processes in the pathogenesis of AD [47].
Numerous studies have revealed that p38 MAPK … mouse model of Alzheimer disease. J. Biol. …
Numerous studies have revealed that p38 MAPK … mouse model of Alzheimer disease. J. Biol. …
[HTML][HTML] SkQ1 suppresses the p38 MAPK signaling pathway involved in Alzheimer's disease-like pathology in OXYS rats
NA Muraleva, NA Stefanova, NG Kolosova - Antioxidants, 2020 - mdpi.com
… As a target protein phosphorylated by components of the p38 MAPK pathway, we examined
the expression of molecular chaperone CryaB and the level of its phosphorylation at the …
the expression of molecular chaperone CryaB and the level of its phosphorylation at the …
[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction
C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
… of Alzheimer’s disease (AD), several studies have shown that the p38 MAPK cascade is …
In recent decades, many reports have shown that the p38 MAPK signaling pathway plays …
In recent decades, many reports have shown that the p38 MAPK signaling pathway plays …
Metabolic reprogramming of microglia enhances proinflammatory cytokine release through EphA2/p38 MAPK pathway in Alzheimer's disease
X Ma, Y Zhang, D Gou, J Ma, J Du… - … of Alzheimer's …, 2022 - content.iospress.com
… This study demonstrated that EphA2/p38 MAPK pathway is involved the release of
proinflammatory cytokines in microglia induced by Aβ 1-42 in AD, which is accompanied by …
proinflammatory cytokines in microglia induced by Aβ 1-42 in AD, which is accompanied by …
[HTML][HTML] When good kinases go rogue: GSK3, p38 MAPK and CDKs as therapeutic targets for Alzheimer's and Huntington's disease
SR D'Mello - International Journal of Molecular Sciences, 2021 - mdpi.com
… indicate cross-talk between the cell cycle machinery and signaling by GSK3 and p38 MAPK.
… As described in this review, kinases including GSK3, p38 MAPK and CDKs affect disease …
… As described in this review, kinases including GSK3, p38 MAPK and CDKs affect disease …
… memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
… Neuroinflammation and oxidative stress have been the predominant pathogenic events
in Alzheimer's disease (AD) which is one of the most common neurodegenerative diseases. …
in Alzheimer's disease (AD) which is one of the most common neurodegenerative diseases. …
[HTML][HTML] miR-146a aggravates cognitive impairment and Alzheimer disease-like pathology by triggering oxidative stress through MAPK signaling
H Zhan-Qiang, Q Hai-Hua, Z Chi, W Miao, Z Cui… - Neurologia, 2023 - Elsevier
… Moreover, the p38 MAPK signaling pathway and ROS production were activated upon …
the levels of APP, ROS, and p-p38 MAPK. A similar phenomenon was also observed in the …
the levels of APP, ROS, and p-p38 MAPK. A similar phenomenon was also observed in the …
P38K and JNK pathways are induced by amyloid-β in astrocyte: Implication of MAPK pathways in astrogliosis in Alzheimer's disease
… To further validate the implication of p38K pathway in Aβ-induced astrocyte … p38, is
phosphorylated upon Aβ treatment. Taken together, our study indicates that p38K and JNK pathways …
phosphorylated upon Aβ treatment. Taken together, our study indicates that p38K and JNK pathways …
Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR
KW Chang, HF Zong, MY Rizvi, KG Ma, W Zhai… - … of Learning and …, 2020 - Elsevier
… Thus, short-term object recognition memory was spared in Aβ-injected mice, and it was
restored by the α7nAChR agonist, p38 MAPK inhibitor, ERK MAPK inhibitor and JNK MAPK …
restored by the α7nAChR agonist, p38 MAPK inhibitor, ERK MAPK inhibitor and JNK MAPK …
The p38 MAPK inhibitors and their role in inflammatory diseases
TR Machado, TR Machado, PG Pascutti - ChemistrySelect, 2021 - Wiley Online Library
… roles of p38 MAPK in the development of chronic inflammation, autoimmunity, Alzheimer's
disease, … p38 MAPK signaling ends through dephosphorylation of both threonine and tyrosine …
disease, … p38 MAPK signaling ends through dephosphorylation of both threonine and tyrosine …
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