ALA‐A2 Is a Novel Anticancer Peptide Inspired by Alpha‐Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and …
T Lerksuthirat, P On‐yam, S Chitphuk… - Global …, 2023 - Wiley Online Library
… -lactalbumin was reported to be inactive for anticancer activity, [ 8 ] but alpha-lactalbumin …
discovery of novel ACPs from potential alpha-lactalbumin peptides. An R-based script was …
discovery of novel ACPs from potential alpha-lactalbumin peptides. An R-based script was …
[HTML][HTML] Effects of lactalbumin enzymatic hydrolysate on human squamous cell carcinoma cells-an in vitro study
APK Arini, W Namangkalakul, P Limraksasin… - Journal of Oral Biology …, 2024 - Elsevier
… Of note, the anti-proliferative activity of LA and its enzymatic hydrolysate derivatives is mainly
related to the apoptosis of tumour cells. Therefore, further studies are needed to investigate …
related to the apoptosis of tumour cells. Therefore, further studies are needed to investigate …
Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis
JT Chiou, YJ Shi, YC Lee, LJ Wang, YJ Chen… - International Journal of …, 2021 - Elsevier
… Self-assembled nanostructural bovine LA (nsLA) shows anticancer activity, while the
structure of LA changes with the formation of nsLA [13]. Altogether, these findings imply that …
structure of LA changes with the formation of nsLA [13]. Altogether, these findings imply that …
[HTML][HTML] A new variant of the human α-lactalbumin-oleic acid complex as an anticancer agent for chronic myeloid leukemia
… lactalbumin as starting material, converted it into the HALOA complex, and then validated its
anti-tumor activity … proteolytic fragments of α-lactalbumin display apoptotic activity. The FEBS …
anti-tumor activity … proteolytic fragments of α-lactalbumin display apoptotic activity. The FEBS …
α-Lactalbumin, amazing calcium-binding protein
EA Permyakov - Biomolecules, 2020 - mdpi.com
… α-LA with lanthanum ion La 3+ [244]. Surprisingly, the complex La 3+ -α-LA exhibited much
stronger anticancer activity against breast cancer cells as compared to the BAMLET (bovine α…
stronger anticancer activity against breast cancer cells as compared to the BAMLET (bovine α…
Effect of whey protein derivatives on cell viability, cell migration and cell cycle phases in MCF-7 cells
… These compounds show anticancer properties by promoting apoptosis, modulating epigenetic
… The cytotoxicity of fatty acid/α‐lactalbumin complexes depends on the amount and type of …
… The cytotoxicity of fatty acid/α‐lactalbumin complexes depends on the amount and type of …
[HTML][HTML] Use of α-lactalbumin [α-La] from whey as a vehicle for bioactive compounds in food technology and pharmaceutics: A review
AP Cuevas-Gómez, IJ Arroyo-Maya… - Recent Progress in …, 2021 - lidsen.com
… α-Lactalbumin (α-La) is a globular protein that can be isolated from WPI (whey protein …
of α-La to form a complex with oleic acid at low pH values and render anticancer properties (…
of α-La to form a complex with oleic acid at low pH values and render anticancer properties (…
[HTML][HTML] Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved …
W Pei, L Cai, X Gong, L Zhang, J Zhang, P Zhu… - Materials Today Bio, 2022 - Elsevier
… By comparison, upon grafting oleic acid onto the surface of MSNs, we found that MSN-BAMLET
exhibited more potent anticancer activity than BAMLET in medium with 20% serum. We …
exhibited more potent anticancer activity than BAMLET in medium with 20% serum. We …
Technological properties and biological activities of camel α-lactalbumin–A review
… by a highly selective apoptotic activity against tumour cells. On the other hand, similar
anticancer activities were reported for the oleic acid-α-La complexes made with α-La isolated from …
anticancer activities were reported for the oleic acid-α-La complexes made with α-La isolated from …
Therapeutic efficacy of α-lactalbumin coated oleic acid based liposomes against colorectal carcinoma in Caco-2 cells and DMH-treated albino rats
EM El-Fakharany, H El‑Gendi… - Journal of …, 2023 - Taylor & Francis
… for lipid and short peptide targeted anticancer activity, the current study hypothesized
synergistic anticancer activity for OA-loaded liposomes coated with camel α-LA. The protein …
synergistic anticancer activity for OA-loaded liposomes coated with camel α-LA. The protein …
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