ALA‐A2 Is a Novel Anticancer Peptide Inspired by AlphaLactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and …

T Lerksuthirat, P On‐yam, S Chitphuk… - Global …, 2023 - Wiley Online Library
… -lactalbumin was reported to be inactive for anticancer activity, [ 8 ] but alpha-lactalbumin
discovery of novel ACPs from potential alpha-lactalbumin peptides. An R-based script was …

[HTML][HTML] Effects of lactalbumin enzymatic hydrolysate on human squamous cell carcinoma cells-an in vitro study

APK Arini, W Namangkalakul, P Limraksasin… - Journal of Oral Biology …, 2024 - Elsevier
… Of note, the anti-proliferative activity of LA and its enzymatic hydrolysate derivatives is mainly
related to the apoptosis of tumour cells. Therefore, further studies are needed to investigate …

Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis

JT Chiou, YJ Shi, YC Lee, LJ Wang, YJ Chen… - International Journal of …, 2021 - Elsevier
… Self-assembled nanostructural bovine LA (nsLA) shows anticancer activity, while the
structure of LA changes with the formation of nsLA [13]. Altogether, these findings imply that …

[HTML][HTML] A new variant of the human α-lactalbumin-oleic acid complex as an anticancer agent for chronic myeloid leukemia

V Singh, R Singh, D Kumar, AA Mahdi… - Journal of Medicine …, 2021 - ncbi.nlm.nih.gov
lactalbumin as starting material, converted it into the HALOA complex, and then validated its
anti-tumor activity … proteolytic fragments of α-lactalbumin display apoptotic activity. The FEBS …

α-Lactalbumin, amazing calcium-binding protein

EA Permyakov - Biomolecules, 2020 - mdpi.com
α-LA with lanthanum ion La 3+ [244]. Surprisingly, the complex La 3+ -α-LA exhibited much
stronger anticancer activity against breast cancer cells as compared to the BAMLET (bovine α

Effect of whey protein derivatives on cell viability, cell migration and cell cycle phases in MCF-7 cells

FT Aksoy, AM Yılmaz, G Bıcım… - Marmara Medical Journal, 2023 - dergipark.org.tr
… These compounds show anticancer properties by promoting apoptosis, modulating epigenetic
… The cytotoxicity of fatty acid/αlactalbumin complexes depends on the amount and type of …

[HTML][HTML] Use of α-lactalbumin [α-La] from whey as a vehicle for bioactive compounds in food technology and pharmaceutics: A review

AP Cuevas-Gómez, IJ Arroyo-Maya… - Recent Progress in …, 2021 - lidsen.com
α-Lactalbumin (α-La) is a globular protein that can be isolated from WPI (whey protein …
of α-La to form a complex with oleic acid at low pH values and render anticancer properties (…

[HTML][HTML] Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved …

W Pei, L Cai, X Gong, L Zhang, J Zhang, P Zhu… - Materials Today Bio, 2022 - Elsevier
… By comparison, upon grafting oleic acid onto the surface of MSNs, we found that MSN-BAMLET
exhibited more potent anticancer activity than BAMLET in medium with 20% serum. We …

Technological properties and biological activities of camel α-lactalbumin–A review

R Lajnaf, H Attia, MA Ayadi - International Dairy Journal, 2023 - Elsevier
… by a highly selective apoptotic activity against tumour cells. On the other hand, similar
anticancer activities were reported for the oleic acid-α-La complexes made with α-La isolated from …

Therapeutic efficacy of α-lactalbumin coated oleic acid based liposomes against colorectal carcinoma in Caco-2 cells and DMH-treated albino rats

EM El-Fakharany, H El‑Gendi… - Journal of …, 2023 - Taylor & Francis
… for lipid and short peptide targeted anticancer activity, the current study hypothesized
synergistic anticancer activity for OA-loaded liposomes coated with camel α-LA. The protein …