Genetics of oocyte maturation defects and early embryo development arrest

OA Solovova, VB Chernykh - Genes, 2022 - mdpi.com
arrest, fertilization failure, early embryo developmental arrest, … TUBB8 gene could be the
cause of zygotic arrest in some embryos … The role of mitochondria and mitochondrial genome in …

Molecular drivers of developmental arrest in the human preimplantation embryo: a systematic review and critical analysis leading to mapping future research

K Sfakianoudis, E Maziotis, E Karantzali… - International journal of …, 2021 - mdpi.com
embryos, unveiling the importance of proper mitochondrial function at the earliest stages of
development [33]. A mitochondrial … HO-1) gene in arrested embryos as an extensive oxidative …

Genetic mechanisms of fertilization failure and early embryonic arrest: a comprehensive review

Y Wei, J Wang, R Qu, W Zhang, Y Tan… - Human …, 2024 - academic.oup.com
… With the progression of meiosis in oocytes, the number of mitochondria continues to increase,
reaching a peak of 100 000 mitochondria and 50 000–550 000 copies of mitochondrial

Embryo and its mitochondria

P May-Panloup, M Boguenet, H El Hachem, PE Bouet… - Antioxidants, 2021 - mdpi.com
embryo, morphologic and functional mitochondrial anomalies, and a modification of the
expression profile of several mitochondrial genes … ovarian aging or embryo cleavage arrest [164]. …

Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation

YL Zhang, W Zheng, P Ren, H Hu, X Tong… - EMBO Molecular …, 2021 - embopress.org
… Our study demonstrated that MOS‐ERK pathway facilitates genes degradation relative to
mitochondria in oocyte, unveiling a new way of ERK1/2 signal pathway for regulating …

Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest

M Tang, M Popovic, P Stamatiadis… - Human …, 2020 - academic.oup.com
… Whole genome amplification (WGA) of embryo samples was performed using the SurePlex
… We further tested whether ST could improve the levels of mitochondrial membrane potential …

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

N Costa-Borges, K Spath, I Miguel-Escalada, E Mestres… - Elife, 2020 - elifesciences.org
… massive embryo developmental arrest characteristic of non-manipulated oocytes. Genetic
… affecting the mitochondrial organelle, which may potentially contribute to certain forms of …

… ? The intricacy of genome structure and gene expression, associated with angiosperm mitochondria, may relate to the regulation of embryo quiescence or dormancy …

C Best, R Mizrahi, O Ostersetzer-Biran - Plants, 2020 - mdpi.com
… as a disruption in the organellar translation machinery, often result in embryo
developmental arrested or lethality phenotypes (see, eg, [91,135,136,137,138,139,140,141,142,143,144]). …

… analysis of cleavage stage embryos and assessment of specific gene expression in cumulus cells independently predict human embryo development to expanded …

S Canosa, L Bergandi, C Macrì, L Charrier… - … and Genetics, 2020 - Springer
… In fact, in the CCs corresponding to embryos with arrested development, we detected a
significantly decreased expression of both COXII and MT-ATP6, markers of mitochondrial

pHi and anabolic arrest during anoxia in Artemia franciscana embryos

SC Hand - Surviving hypoxia, 2022 - taylorfrancis.com
arrest within mitochondria, either directly or indirectly, is difficult to approach in vivo with the
intact embryo… the major proteins encoded by the mitochondrial genome are few in number, …