Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
… similarity searches: polyketide synthases (PKSs), non-ribosomal peptide synthetases (NRPSs)
and ribosomally synthesized and post-translationally modified peptides (RiPPs), as well …
and ribosomally synthesized and post-translationally modified peptides (RiPPs), as well …
A review on the diversity of antimicrobial peptides and genome mining strategies for their prediction
… modified peptides (RiPPs) and non-ribosomal peptides (… translationally modified peptide
synthetase (RiPP synthetase)… approaches to understand microbial genomes and DNA structure/…
synthetase (RiPP synthetase)… approaches to understand microbial genomes and DNA structure/…
Mining the Genome of Bacillus velezensis VB7 (CP047587) for MAMP Genes and Non-Ribosomal Peptide Synthetase Gene Clusters Conferring Antiviral and …
… , were observed in the genome of BZR 336g [47]. Similarly, the draft genome sequence of
our study isolate VB7 revealed the presence of anti-microbial peptide genes, such as surfactin, …
our study isolate VB7 revealed the presence of anti-microbial peptide genes, such as surfactin, …
Marine bacterial ribosomal peptides: recent genomics-and synthetic biology-based discoveries and biosynthetic studies
L Sukmarini - Marine Drugs, 2022 - mdpi.com
… were initially assumed non-ribosomal peptide synthetase products and divamide A from …
global analysis of BGCs in marine bacteria genomes has revealed that RiPPs biosynthesis …
global analysis of BGCs in marine bacteria genomes has revealed that RiPPs biosynthesis …
Molecular basis of a bacterial-amphibian symbiosis revealed by comparative genomics, modeling, and functional testing
… peptide synthetase putatively involved in the synthesis of methoxypyrazines (p. MOPs
cluster, orange); circle 6, the five two-component system genes (TCSs, red) and eight multidrug …
cluster, orange); circle 6, the five two-component system genes (TCSs, red) and eight multidrug …
Genomic and gene expression evidence of nonribosomal peptide and polyketide production among ruminal bacteria: a potential role in niche colonization?
SM Moreira, TA de Oliveira Mendes… - FEMS Microbiology …, 2020 - academic.oup.com
… for the muti-domain polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS)
were identified in the ruminal microbial genomes investigated in this study (Table S5, …
were identified in the ruminal microbial genomes investigated in this study (Table S5, …
AdenPredictor: accurate prediction of the adenylation domain specificity of nonribosomal peptide biosynthetic gene clusters in microbial genomes
M Mongia, R Baral, A Adduri, D Yan, Y Liu… - …, 2023 - academic.oup.com
… The discovery of novel NRPs remains a laborious process because many NRPs consist
of nonstandard amino acids that are assembled by nonribosomal peptide synthetases (NRPSs). …
of nonstandard amino acids that are assembled by nonribosomal peptide synthetases (NRPSs). …
Targeting bacterial genomes for natural product discovery
E Kalkreuter, G Pan, AJ Cepeda, B Shen - Trends in Pharmacological …, 2020 - cell.com
… (eg, polyketides, peptides, terpenes, etc.) and, in some cases, the core structures of the NPs
[eg, products of type I polyketide synthases (PKSs) and nonribosomal peptide synthetases (…
[eg, products of type I polyketide synthases (PKSs) and nonribosomal peptide synthetases (…
Rhodococcus comparative genomics reveals a phylogenomic-dependent non-ribosomal peptide synthetase distribution: insights into biosynthetic gene cluster …
… genomic information with the production of NPs, especially to orphan metabolites. This study
performed a comparative genomics … by non-ribosomal peptide synthetase (NRPS) pathways…
performed a comparative genomics … by non-ribosomal peptide synthetase (NRPS) pathways…
Nonribosomal peptide synthesis definitely working out of the rules
M Duban, S Cociancich, V Leclère - Microorganisms, 2022 - mdpi.com
… enzymes called nonribosomal peptide synthetases. These … of thousands of available microbial
genomes allow us to pinpoint … microbial metabolic diversity found in nonribosomal peptide …
genomes allow us to pinpoint … microbial metabolic diversity found in nonribosomal peptide …
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