… Buprenorphine and its metabolite, norbuprenorphine, were quantified from plasma … IV bolus
injection in pregnant sheep. Plasma samples were collected up to 48 h after administration, …

… (120 μg kg –1 in Doodnaught et al., 20 μg kg –1 in Johnson et al., 40 μg kg –1 in the current
study); mode of administration (intravenous bolus in Doodnaught et al. and Johnson et al., …

… for buprenorphine and norbuprenorphine after intravenous and sublingual administration …
BUP Cp total residue after receiving a loading IV bolus dose followed by an IV infusion. Finally, …

… Buprenorphine and its active metabolite norbuprenorphine have both agonist and … (PCA
settings should include boluses only, as the patient’s baseline buprenorphine should take the …

… The average combined bolus + infusion 24-hour dose of BUP was 972 μg … of buprenorphine
active metabolites norbuprenorphine, buprenorphine-3-glucuronide, and norbuprenorphine-…

… precision deuteration alters in vivo buprenorphine effects. Last, we compared NorBUP
blood concentration-time profiles up to 12 h after bolus intravenous administration of BUP-D2 …

… use, a single bolus dose of methadone has not been … Norbuprenorphine is 25% as potent
as buprenorphine and may be more likely to cause respiratory depression than buprenorphine…

… other opioids, reversal of buprenorphine-induced ventilatory … ) and to require a higher bolus
and infusion dose [1]. These … actually caused by increased norbuprenorphine brain uptake …

… Buprenorphine HCl and norbuprenorphine were purchased as 1 mg/mL …
Buprenorphine-3-beta-D-glucuronide, norbuprenorphine glucuronide, and the internal standards …

… the proportion of circulating norbuprenorphine but did not worsen buprenorphine-induced …
The selected dose of buprenorphine used to precipitate the DDI (0.2 mg iv bolus, which …