Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
… understanding of the pathophysiology of TBI, the underlying mechanisms still need to be …
pathophysiological mechanism of TBI and various biochemical pathways involved in brain injury

[HTML][HTML] Traumatic brain injury and blood–brain barrier (BBB): underlying pathophysiological mechanisms and the influence of cigarette smoking as a premorbid …

F Sivandzade, F Alqahtani, L Cucullo - International journal of molecular …, 2020 - mdpi.com
… Traumatic brain injury (TBI) is among the most pressing … In addition to the brain injury, TBI
may also alter the systemic … that brain injury leads to impairments of the blood–brain barrier (…

[HTML][HTML] Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
… Traumatic brain injury pathophysiology involves two types of damage: primary and
secondary. Primary damage refers to the brain damage produced by the external force itself. It …

The pathophysiology of traumatic brain injury

CC Giza, DA Hovda - Traumatic brain injury in sports, 2020 - taylorfrancis.com
… for sports-related concussion, including the post-concussive window of vulnerability,
consequences of multiple successive brain injuries, overuse injury, and developmental brain injury. …

Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets

S Sulhan, KA Lyon, LA Shapiro… - Journal of neuroscience …, 2020 - Wiley Online Library
… This review focuses on the mechanisms involved in traumatic brain injury, separating them
mechanisms have been isolated in the hours to days following a traumatic brain injury that …

Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management

A Capizzi, J Woo, M Verduzco-Gutierrez - Medical Clinics, 2020 - medical.theclinics.com
… The goal of this article is to provide a general review of the epidemiology, acute care, and
chronic management of adult patients with traumatic brain injuries (TBI). This text was created …

[HTML][HTML] Pathophysiological responses and roles of astrocytes in traumatic brain injury

S Michinaga, Y Koyama - International journal of molecular sciences, 2021 - mdpi.com
… Traumatic brain injury (TBI) is severe damage to the brain and is referred to as a sudden
insult caused by traffic accidents, falls, and sporting activity. TBI is a primary cause of …

[HTML][HTML] Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
… However, the pathological mechanisms connecting these two processes have not yet
been fully elucidated. It is important to further investigate the pathophysiological mechanisms

[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
… In conclusion, a comprehensive understanding of TBI pathophysiology will allow for the
development of effective drugs or drug combinations that target multiple secondary …

[HTML][HTML] DAMPs and RAGE pathophysiology at the acute phase of brain injury: an overview

B Balança, L Desmurs, J Grelier… - International Journal of …, 2021 - mdpi.com
… ” or “S100B” and “traumatic brain injury” or “subarachnoid hemorrhage” or “… brain injury
pathophysiology, from which we describe DAMPs release and clearance upon acute brain injury, …