SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca2+-dependent manner by cAMP and ATP in intestinal epithelial cells

R Sarker, R Lin, V Singh… - American Journal of …, 2023 - journals.physiology.org
… , in which their actions are independent, additive, synergistic, or … both elevated cAMP and
Ca 2+ stimulated DRA activity and … Ca 2+ stimulates DRA activity in polarized human intestinal

Bicarbonate secretion and acid/base sensing by the intestine

HM Becker, UE Seidler - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
… of CFTR-dependent, agonist-stimulated HCO 3 − secretion is a … in murine as well as human
intestine: The agonist-induced … a highly expressed and cAMP-insensitive SLC26A3 [145, 166]…

The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus …

PL Ljungholm, A Ermund… - … -European Journal of …, 2024 - Springer
… , CCh induces de novo mucus secretion via Cftr-dependent processes, while PGE 2 … and
Ptger3 that inhibits cAMP production [43]. A similar pattern is seen in human colonic goblet cells …

Slc26a3 (DRA) in the gut: expression, function, regulation, role in infectious diarrhea and inflammatory bowel disease

Q Yu - Inflammatory Bowel Diseases, 2021 - academic.oup.com
… The upregulation of cAMP level in intestinal epithelial cells inhibits … that cAMP
stimulates DRA activity in HEK293/DRA cells, Caco2 cells, and human colonoids in a CFTR-dependent

Pathogenic relationships in cystic fibrosis and renal diseases: CFTR, SLC26A9 and anoctamins

K Kunzelmann, J Ousingsawat, A Kraus… - International journal of …, 2023 - mdpi.com
is facilitated by exchange proteins directly activated by cAMP … -dependent transport,
CFTR-dependent Cl − transport was … Like other SLC26A proteins (SLC26A3,4,6,8), SLC26A9 may

Pathogenic Relationships in Cystic Fibrosis: CFTR, SLC26A9 and Anoctamins

K Kunzelmann, J Ousingsawat, A Kraus, JH Park… - 2023 - preprints.org
… proteins (SLC26A3,4,6,8), also SLC26A9 may interact … secretagogues and cAMP or
Ca2+dependent stimulation. It … -dependent transport, also CFTR-dependent Cl- transport was lost …

Physiological and pathological functions of SLC26A6

J Wang, W Wang, H Wang, B Tuo - Frontiers in Medicine, 2021 - frontiersin.org
… agree that not only human but also mouse SLC26A3 Cl − / … stimulating conditions, HCO
3 - secretion depends critically upon the activity of CFTR anion channel (49) which is a cAMP-…

The Physiology of Epithelial ION and Fluid Transport: Beyond CFTR Modulators

L Delpiano, MA Gray - Hodson and Geddes' Cystic Fibrosis, 2023 - taylorfrancis.com
… by a mechanism that includes both CFTR-dependent and … Furthermore, the transport
activity of SLC26A3 and A6 are … in cytosolic Ca2+ can stimulate the production of cAMP via the …

Oxalate secretion is stimulated by a cAMP-dependent pathway in the mouse cecum

JM Whittamore, M Hatch - Pflügers Archiv-European Journal of Physiology, 2023 - Springer
… second messenger cAMP can stimulate intestinal oxalate … DRA (Down-Regulated in Adenoma;
Slc26a3), has been shown to … membrane in human colon [24], DTDST is also abundantly …

SLC26A9 in airways and intestine: secretion or absorption?

K Kunzelmann, R Centeio, J Ousingsawat, K Talbi… - Channels, 2023 - Taylor & Francis
… deflection due to activation of CFTR-dependent Cl- secretion. … activity in the absence of an
increase in intracellular cAMP … for pancreatic SLC26A3 and SLC26A6, which is likely to be …