… evidence on different cell death mechanisms that have been associated with photoreceptor
degeneration, … A special focus is then put on the mechanisms of cGMP-dependent cell death …

… leads to its accumulation, CNG channel deficiency results in a … Evidence supporting the
contribution of the elevated cGMP … models with PDE6 deficiency and CNG channel deficiency. …

… photoreceptor degeneration. The topics covered include … OSs activate the cyclic
nucleotide–gated channel (CNGC) to allow … is achromatopsia where the genetic defect resides in …

… Since the CNG channel is absent from Cnga3 KO cones, we explored the expression of …
photoreceptors also accumulate exuberant levels of cGMP due to lack of the cone CNG channel …

… cGMP, leading to CNG channel closure and photoreceptor … followed by degeneration
and loss of rod photoreceptors, which … for rod CNG channel models, Cnga3- and Cngb3-deficient …

… where a genetic defect causes cone degeneration without … darkness, cGMP opens the
cyclic nucleotide-gated channel (… affect the accumulation of cGMP in rd1 photoreceptors. Even …

… of photoreceptor degeneration in CNG channel deficiency and provides a better understanding
of how cGMP/PKG signaling induces photoreceptor … further provided evidence that cGMP/…

… of LCPUFA oxidation is the accumulation of ROS also in the … + influx through the cyclic
nucleotide-gated channel (CNGC), … , high cGMP can cause photoreceptor degeneration through …

… based on an accumulation of cGMP in photoreceptors and … degenerative pathway triggered
by high levels of cGMP in … , in which the rod photoreceptor CNG channel was not functional. …

… -6 (PDE6) enzyme, which leads to the elevated accumulation of intracellular cGMP in … of
blocking Cyclic Nucleotide Gated Channels (CNGC) on the photoreceptor degeneration. This …