… PAH metabolites by the conjugating enzyme system (not shown) fails, reactive PAH-diol
epoxides may covalently bind to the DNA and form highly mutagenic bulky DNA adducts. …

… MC-LR inhibited AFB1 induced upregulation of cytochrome P450 family 1 subfamily A member
2 (CYP1A2) and reduced the AFB1-DNA adducts generation in both human hepatic cells …

… First, we investigated DNA adduct formation in human HepG2 liver cells, since the liver is …
by ME-derived DNA adducts triggers mitochondrial apoptotic cell death via Bax activation, …

… recently described rapid approach to DNA adduct recovery (RADAR) assay to analyse the
abundance of proteins covalently attached to DNA 34 . By lysing cells in chaotropic salts (6 M …

… -DNA methyltransferase (MGMT), an enzyme required for repair of DNA adducts from alkylating
… to interact with DNA directly and the end product is an ethyl-adduct. The most common …

… cross-link with DNA to form cisplatin-DNA adducts and induce DNA double-strand … cell
apoptosis and killing tumor cells (Figure 3b). When DNA is damaged, the body will activate DNA …

… cell culture cells so far. In this paper, we expand the detection of cisplatin-induced DNA adducts
… line MDA-MB-231, human squamous cell carcinoma cell line UTSCC24A and UTSCC2, …

… ) cause DNA damage by generating DNA adducts, impairing DNA synthesis or by interfering
with mitosis, thereby eventually triggering cell death. cAT-induced DNA damage activates a …

… in tobacco causes DNA adducts. Genetic polymorphisms can affect metabolic activation of
the carcinogens and will determine the DNA adduct levels. These DNA adducts if not repaired …

… microsomes in vitro to form DNA adducts, with N(deoxyguanosin8 … induces this DNA adduct
and causes DNA damage.… and transitional cell carcinoma, and mononuclear cell leukaemia. …