… B cells differ in their affinity for antigen throughout … cell receptor affinity for antigen is one of
the important determinants in the cell fate decision for plasma cell and GC B cell differentiation…

… of the cell product. For most applications, the requisite purity is only achievable through affinity
… for developing cell-targeting affinity ligands and their application in cell purification, along …

… of antigen valency during different phases of B cell responses … activated cognate B cells,
with little affinity discrimination. This … antigen valencies on B cell activation, B cell differentiation, …

… in CD8 + T cell differentiation of effector and memory cells (3). Although Ag affinity has
been … to make separate contributions to T cell activation (17–20). Furthermore, whereas low-…

… IL-2 production and Tfh cell differentiation correlated with TCR signal … cell differentiation.
Interestingly, it has been reported that low-affinity antigen did not impact Tfh cell differentiation […

… effector T cell differentiation and a holistic view of CD4 + T cell … how Teff and Tfh cells
differentiate from naive precursors, as … differentiation, while those activated by low-affinity antigen …

… T-cell clones of high affinity against self-antigens are usually eliminated. Therefore, the frequency
of high-affinity TCRs towards TAAs in circulating T-cells is … an inferior T-cell response to …

… affinity allow CARTs to differentiate tumor cells from normal cells based on quantitative
antigen difference, which will broaden the targetable tumor-associated surface antigens that can …

… Here we review CD8 + T cell differentiation to dysfunctional states … T cell dysfunction and
other hyporesponsive T cell states and discuss the spatio-temporal factors contributing to T cell …

… Memory B cells (MBCs) can respond to heterologous antigens … preexisting clones without
further affinity maturation. To distinguish … of antigen-dependent murine B cell differentiation and …