… We suggest that DNAme turnover can also contribute to stochasticity, symmetry breaking
and the emergence of different cell lineages from the same pool of stem cells upon exposure to …

… cell phenotype, and its dysregulation in diabetes. We will also review recent advances in
utilizing beta cell specific DNA methylation … identity: Hypermethylation of the alpha cell lineage …

… It has been well established that helper T cell lineages, eg, Th1, Th2, and Th17 cells that
produce distinct effector molecules, are induced by discrete environmental cues to express …

… specification of immune cell lineages, but patterns that uniquely define immune cell types
and … Here, we identified lineage-specific DNA methylation signatures of six immune cell types …

… of the alveolar cell lineage 27 . Some methylation patterns were common to lineages that
formed … For example, 892 regions were unmethylated in epithelial cells derived from early …

… -timescale dynamics of cell renewal in adult tissues. Here, we show that fluctuating DNA
methylation marks can be used as clocks in cells where ongoing methylation and demethylation …

… DAPI was used to exclude dead cells. The composition of mature hematopoietic cell lineages
in the bone marrow was assessed using a combination of antibodies against B220, CD19, …

… with SCLC lineage subgroups, we analyzed Spearman and Pearson correlation of DNA
methylation of individual probes and gene regions with expression of six lineage SCLC markers…

… profiles include information from multiple cell lineages and, in some cases, cell states. Every
cell lineage has unique DNA methylation patterning regulating cell-specific gene expression…

… DNA methylation patterns are very dynamic, with different and characteristic patterns for
myeloid and lymphoid lineages … ]], emerging evidence shows cell lineage conversion, often as a …