Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets

J Krushkal, T Silvers, WC Reinhold, D Sonkin… - Clinical …, 2020 - Springer
… with SCLC lineage subgroups, we analyzed Spearman and Pearson correlation of DNA
methylation of individual probes and gene regions with expression of six lineage SCLC markers…

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

LA Salas, Z Zhang, DC Koestler, RA Butler… - Nature …, 2022 - nature.com
… profiles include information from multiple cell lineages and, in some cases, cell states. Every
cell lineage has unique DNA methylation patterning regulating cell-specific gene expression…

[HTML][HTML] Navigating the DNA methylation landscape of cancer

A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …

Evolution of DNA methylation in the human brain

H Jeong, I Mendizabal, S Berto, P Chatterjee… - Nature …, 2021 - nature.com
… Using matched gene expression data, we show that this locus is upregulated in a cell-type
and lineage-specific manner in human neurons (Fig. 2c), consistent with the role of human-…

The DNA methylation landscape of hematological malignancies: an update

P Blecua, L Martinez‐Verbo, M Esteller - Molecular Oncology, 2020 - Wiley Online Library
DNA methylation patterns are very dynamic, with different and characteristic patterns for
myeloid and lymphoid lineages … ]], emerging evidence shows cell lineage conversion, often as a …

Epigenetic regulators of mesenchymal stem/stromal cell lineage determination

D Cakouros, S Gronthos - Current osteoporosis reports, 2020 - Springer
… This review discusses how specific enzymes that modify histone methylation and acetylation
or DNA methylation orchestrate the differentiation programs in lineage determination of …

DNA methylation biomarkers for nasopharyngeal carcinoma

B Han, X Yang, P Zhang, Y Zhang, Y Tu, Z He, Y Li… - PLoS …, 2020 - journals.plos.org
… Pathway analysis indicated enrichment in B cell receptor signaling pathway, Hematopoietic
cell lineage, Leukocyte transendothelial migration, Complement and coagulation cascades …

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

M Duran-Ferrer, G Clot, F Nadeu, R Beekman… - Nature Cancer, 2020 - nature.com
… We report a systematic analysis of the DNA methylation variability in 1,595 samples of
normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. …

Cell division drives DNA methylation loss in late-replicating domains in primary human cells

JL Endicott, PA Nolte, H Shen, PW Laird - Nature Communications, 2022 - nature.com
… PDs, suggesting that RepliTali may be best suited to compare relative proliferative histories
within a given cellular lineage. As the model was trained upon homogeneous primary …

A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes

C You, S Wu, SC Zheng, T Zhu, H Jing, K Flagg… - Nature …, 2020 - nature.com
… subtypes or if they are cell-type specific. Here, we apply a cell-type deconvolution algorithm
to identify cell-type specific DNA methylation signals in seven large EWAS. We find that most …