Cellular senescence in brain aging
E Sikora, A Bielak-Zmijewska, M Dudkowska… - Frontiers in aging …, 2021 - frontiersin.org
… In this review, we ask questions about the role of senescent brain cells in brain plasticity
and cognitive functions impairments and how senolytics can improve them. We will discuss …
and cognitive functions impairments and how senolytics can improve them. We will discuss …
The cellular senescence stress response in post-mitotic brain cells: cell survival at the expense of tissue degeneration
E Sah, S Krishnamurthy, MY Ahmidouch, GJ Gillispie… - Life, 2021 - mdpi.com
… In the following sections, we review studies reporting senescence in post-mitotic brain cells.
We evaluate the methods used by key studies and compare them to our pre-defined criteria …
We evaluate the methods used by key studies and compare them to our pre-defined criteria …
Evidence of the cellular senescence stress response in mitotically active brain cells—implications for cancer and neurodegeneration
GJ Gillispie, E Sah, S Krishnamurthy, MY Ahmidouch… - Life, 2021 - mdpi.com
… analyses have not included senescent cells in the brain. To … cellular senescence with cell
type specificity, and not bulk analyses. We specifically focus on mitotically competent brain cells…
type specificity, and not bulk analyses. We specifically focus on mitotically competent brain cells…
Aging, cellular senescence, and Alzheimer's disease
RM Liu - International journal of molecular sciences, 2022 - mdpi.com
… Emerging evidence shows that various types of brain cells, including oligodendrocyte
precursor cells (OPCs), astrocytes, microglia, and neurons, express higher levels of …
precursor cells (OPCs), astrocytes, microglia, and neurons, express higher levels of …
[HTML][HTML] Evidence and perspectives of cell senescence in neurodegenerative diseases
Z Si, L Sun, X Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
… senescent cells in neurodegenerative diseases. In the final section, we review how cell
senescence … Cell senescence on these types of brain cells may lead to impaired myelination and …
senescence … Cell senescence on these types of brain cells may lead to impaired myelination and …
Cellular senescence at the crossroads of inflammation and Alzheimer's disease
A Guerrero, B De Strooper… - Trends in …, 2021 - cell.com
… The question arises whether senescence-induced inflammation … of cellular senescence
as a driver of the aging phenotype, and discuss the current evidence that connects senescence …
as a driver of the aging phenotype, and discuss the current evidence that connects senescence …
Cellular senescence in neurodegenerative diseases
C Martínez-Cué, N Rueda - Frontiers in cellular neuroscience, 2020 - frontiersin.org
… This review summarizes the main findings on the role of cellular senescence in the … cell
cycle arrest associated with cellular senescence, the reduced regenerative capacities of the brain …
cycle arrest associated with cellular senescence, the reduced regenerative capacities of the brain …
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
S Saez-Atienzar, E Masliah - Nature Reviews Neuroscience, 2020 - nature.com
… are not cleared then the accumulation of senescent cells becomes greater with time, … as a
pro-senescence stimulus and induces cellular senescence in different brain cell types, leading …
pro-senescence stimulus and induces cellular senescence in different brain cell types, leading …
Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain
SI Graves, DJ Baker - Basic & clinical pharmacology & …, 2020 - Wiley Online Library
… to DNA damage or other cellular stresses. We discuss evidence for endothelial cell senescence
in ageing and cardiovascular disease, and how CEC senescence may contribute to age-…
in ageing and cardiovascular disease, and how CEC senescence may contribute to age-…
Cell senescence in neuropathology: A focus on neurodegeneration and tumours
G Carreno, R Guiho… - Neuropathology and …, 2021 - Wiley Online Library
… In this review we will discuss the role of senescent cells in brain pathologies, in particular
age-associated neurodegenerative diseases such as Alzheimer's disease, Parkinson's …
age-associated neurodegenerative diseases such as Alzheimer's disease, Parkinson's …
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