Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …

… were identified from different clinical samples by conventional … Extended-spectrum beta-lactamase,
Metallo-β-lactamase, and … PCR also detected different β lactamase genes and …

… hormaechei clinical isolate in this study was part of the routine hospital laboratory procedure,
the Ethics Committee of the Shanghai Pulmonary Hospital of Tongji University School of …

… -lactamases have multiplied dramatically during the last decades, and the evolution of β-lactamases
found in clinical isolates … Although there are almost 4900 β-lactamases, as unique …

… of 338 GNB isolates were isolated from different clinical samples … The GNB isolates, the types
of beta-lactamases and the … coli clinical isolates in affiliated hospitals of Babol University of …

… All four clusters (A–D) carry RMNRE residues in the 235–245 region (33), and this key
feature was observed in clinical isolates able to generate extended-spectrum AmpC β-lactamases …

… of β-lactam antibiotics with β-lactamase inhibitors, which are … the clinic for overcoming
resistance by inhibiting β-lactamases. … serine β-lactamases, but several of class D and B (metallo-β-…

… could also facilitate expedient pairings to suit unique clinical needs (eg, readily pairing
aztreonam with avibactam against isolates suspected of harboring class A and B β-lactamases). …

… by the introduction of some SHV-type β-lactamase (Table 2). These results suggest that …
isolates in this study could be due to the co-expression of NDM and serine-type β-lactamases …

… of non-beta-lactamase-mediated general intrinsic resistance mechanisms, and (iii)
activity of combinations with QPX7728 against clinical isolates producing diverse beta-lactamases. …