Resistance to novel β-lactamβ-lactamase inhibitor combinations: the “price of progress”

KM Papp-Wallace, AR Mack, MA Taracila… - Infectious Disease …, 2020 - id.theclinics.com
… Given their effectiveness, the development of resistance to β-lactam antibiotics creates a …
This review focuses on the emergence of resistance to the 4 novel β-lactamβ-lactamase

Distribution of Class B and Class A β-Lactamases in Clinical Strains of Pseudomonas aeruginosa: Comparison of Phenotypic Methods and High-Resolution Melting …

S Dehbashi, H Tahmasebi, MY Alikhani… - Infection and Drug …, 2020 - Taylor & Francis
… First, the present study was conducted on a small number of clinical isolates of P. aeruginosa,
while in order to reach a definitive and complete result, the population of the population …

[HTML][HTML] Molecular characteristics of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Japan: Predominance of CTX-M-15 and emergence of …

N Kakuta, R Nakano, A Nakano, Y Suzuki… - International Journal of …, 2020 - Elsevier
… A total of 100 clinical isolates of ESBL-producing K. pneumoniae collected throughout
Japan between June and July 2018 were studied. ESBL genes were analyzed using PCR and …

[HTML][HTML] Molecular analysis of clinical isolates of ceftazidime-avibactam-resistant Klebsiella pneumoniae

C Venditti, O Butera, M Meledandri, MP Balice… - Clinical Microbiology …, 2021 - Elsevier
… In this paper, we describe the results of a 1-year molecular analysis of all ceftazidime-avibactam-resistant
clinical isolates collected from six hospitals in Rome. The strains studied, all …

… bla OXA48-bla KPC-bla NDM-bla VIM and extended-spectrum-β-lactamase bla OXA1-bla SHV-bla TEM genes in Gram-negative bacterial isolates from ICU burns …

MH Haider, TD McHugh, K Roulston, LB Arruda… - Annals of Clinical …, 2022 - Springer
… carbapenemase-producing clinical isolates which provides a presumptive diagnosis to inform
rapidly the selection of antibiotic therapy: an exceptional diagnostic and clinical strategy is …

Metallo-β-lactamases: structure, function, epidemiology, treatment options, and the development pipeline

SE Boyd, DM Livermore, DC Hooper… - Antimicrobial agents …, 2020 - Am Soc Microbiol
… -encoded metallo-β-lactamase (VIM) and New Delhi metallo-β-lactamase (NDM). The first
acquired MBL (imipenemase; IMP-1), was reported from clinical isolates of P. aeruginosa and …

Investigation of mechanisms responsible for decreased susceptibility of aztreonam/avibactam activity in clinical isolates of Enterobacterales collected in Europe, Asia …

RE Mendes, TB Doyle, JM Streit… - Journal of …, 2021 - academic.oup.com
Isolates possessing an altered PBP3 and bla NDM would be refractory to aztreonam/avibactam
and any clinically available β-lactams and β-lactam/BLI combinations. Recent studies …

Prevalence of metallo-β-lactamases as a correlate of multidrug resistance among clinical Pseudomonas aeruginosa isolates in Nepal

P Dawadi, C Khadka, M Shyaula, G Syangtan… - Science of The Total …, 2022 - Elsevier
… We conclude that MBL producing strains are widespread among the clinical isolates of P.
aeruginosa in Nepal and responsible for emerging MDR strains. It is paramount that antibiotics …

High prevalence of Escherichia coli clinical isolates in India harbouring four amino acid inserts in PBP3 adversely impacting activity of aztreonam/avibactam

H Periasamy, P Joshi, S Palwe… - Journal of …, 2020 - academic.oup.com
… coli clinical isolates with an ability to evade the onslaught of PBP3-targeting β-lactams
through … However, conceivably this was imminent, as β-lactams employed for Gram-negative …

Microbiological Characteristics of Carbapenem-Resistant Enterobacteriaceae Clinical Isolates Collected from County Hospitals

S Xie, S Fu, M Li, Z Guo, X Zhu, J Ren… - Infection and Drug …, 2020 - Taylor & Francis
… with any of the clinical isolates. No carbapenemase gene was detected for four isolates in
this study and … Two isolates were negative for all of β-lactamase gene detected in this study. …