Molecularly classified uterine FIGO grade 3 endometrioid carcinomas show distinctive clinical outcomes but overlapping morphologic features

A Joehlin-Price, J Van Ziffle, NK Hills… - The American Journal …, 2021 - journals.lww.com
… Aberrant staining for p53 was defined as either strong diffuse nuclear staining in >75% of …
In addition, only 3 of these 5 mutations are found in the exon 3 region of CTNNB1, considered …

[HTML][HTML] Exon-skipping in Duchenne muscular dystrophy

S Takeda, PR Clemens… - Journal of neuromuscular …, 2021 - content.iospress.com
… Efforts to predict the clinical outcomes of different in-frame deletions based on systematic …
bulk delivery of any DNA or RNA payload to either normal or dystrophic muscle. Most cell types …

Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes

HJ Tadros, CS Life, G Garcia, E Pirozzi… - Journal of molecular and …, 2020 - Elsevier
… TNNC1-positive probands had younger ages of diagnosis and poorer clinical outcomes.
Mapping of TNN variants identified locations in TNNT2 and TNNI3 associated with heightened …

[HTML][HTML] Targeted next-generation sequencing of 117 routine clinical samples provides further insights into the molecular landscape of uveal melanoma

S Thornton, SE Coupland, L Olohan, JS Sibbring… - Cancers, 2020 - mdpi.com
… UM clinical samples processed either as fresh-frozen, formalin-fixed paraffin embedded (…
D630N on exon 20 [18]. The mutation identified in our study occurred in exon 18 and is the first …

[HTML][HTML] Selective KRAS G12C inhibitors in non-small cell lung cancer: chemistry, concurrent pathway alterations, and clinical outcomes

G Palma, F Khurshid, K Lu, B Woodward… - NPJ Precision …, 2021 - nature.com
… Ib/II clinical trial as a monotherapy and in combination with either TNO155 or spartalizumab
(… JUNIPER clinical trials against erlotinib in patients with KRAS mutant (exon 12 or exon 13) …

[HTML][HTML] Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome

RL Hollis, JP Thomson, B Stanley… - Nature …, 2020 - nature.com
Endometrioid ovarian carcinoma (EnOC) demonstrates substantial clinical and molecular
heterogeneity. Here, we report whole exome sequencing of 112 EnOC cases following …

[HTML][HTML] Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions

C Zhou, KJ Tang, BC Cho, B Liu… - … England Journal of …, 2023 - Mass Medical Soc
… The most common adverse events that were reported in at least 15% of the patients in either
… treatments, which do not improve clinical outcomes as compared with chemotherapy alone …

[HTML][HTML] Real-world experience in treatment of patients with non-small-cell lung cancer with Braf or Cmet exon 14 skipping mutations

U Janzic, W Shalata, K Szymczak… - International Journal of …, 2023 - mdpi.com
… oncogene-addicted NSCLC with either a BRAF or MET exon 14 skipping mutation might …
TT, with 3/4 achieving a clinical benefit. As for the MET exon 14 skipping mutation patients, 6/36 …

The impact of osimertinib'line on clonal evolution in EGFRm NSCLC through NGS-based liquid biopsy and overcoming strategies for resistance

V Fuchs, L Roisman, W Kian, L Daniel, J Dudnik… - Lung Cancer, 2021 - Elsevier
… Furthermore, we followed clinical outcomes of select patients … patients with tumors harboring
either exon 19 deletion, L858R or … T790 M was diagnosed either in the tumor specimen or in …

Newborn screening for spinal muscular atrophy in New York state: clinical outcomes from the first 3 years

BH Lee, S Deng, CA Chiriboga, DM Kay… - Neurology, 2022 - AAN Enterprises
… data obtained from a subgroup of patients (n = 11) demonstrated either improvement or no
… of exon 7 of the SMN1 gene encoding the survival motor neuron (SMN) protein. The clinical