Clinical Outcomes in Patients with Multi-Hit TP53 Chronic Lymphocytic Leukemia Treated with Ibrutinib
C Brieghel, K Aarup, MH Torp, MA Andersen… - Clinical Cancer …, 2021 - AACR
… to investigate clinical outcomes in 51 patients treated with ibrutinib carrying either a single …
initiation of ibrutinib for mutations in the TP53 gene (exons 2–10 +2 base-pair intronic overlap) …
initiation of ibrutinib for mutations in the TP53 gene (exons 2–10 +2 base-pair intronic overlap) …
[HTML][HTML] Germline cancer susceptibility gene testing in unselected patients with colorectal adenocarcinoma: a multicenter prospective study
PLS Uson Jr, D Riegert-Johnson, L Boardman… - Clinical …, 2022 - Elsevier
… approach, association with clinical outcomes, and the uptake of family variant testing. … coding
exons, 10–20 base pairs of adjacent intronic sequencing on either side of the coding exons…
exons, 10–20 base pairs of adjacent intronic sequencing on either side of the coding exons…
Pretransplant FLT3-ITD MRD assessed by high-sensitivity PCR-NGS determines posttransplant clinical outcome
S Loo, R Dillon, A Ivey, NS Anstee… - Blood, The Journal …, 2022 - ashpublications.org
… Amplicon-based PCR-NGS of exons 14 to 15 detected FLT3-ITDs of at least 6 base pairs to
a … Interestingly, intermediate RFS and OS were observed for patients positive for either NPM1 …
a … Interestingly, intermediate RFS and OS were observed for patients positive for either NPM1 …
HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia
… HLA-A and 2 mutations in cytoplasmic tail (exon 7) of HLA-C (… least 2 years before the clinical
diagnosis of clonal evolution … expand and become clinically evident, either by accumulating …
diagnosis of clonal evolution … expand and become clinically evident, either by accumulating …
NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes
… encoding CMV-Cre-recombinase to delete exons 2–3 of Keap1 and exons 3–6 of Stk11 in
the … were only upregulated in clinical samples, suggesting they may either represent context-…
the … were only upregulated in clinical samples, suggesting they may either represent context-…
Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck
A Agaimy, JK Dermawan, I Leong… - Genes …, 2022 - Wiley Online Library
… All VGLL3 fusions were in-frame and involved exon 2, fused with either TCF12 exon 16,
EP300 exon 31, or PPARGC1A exon 5, respectively. This series characterizes a distinctive …
EP300 exon 31, or PPARGC1A exon 5, respectively. This series characterizes a distinctive …
Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant
SM Tolaney, M Toi, P Neven, J Sohn, EM Grischke… - Clinical Cancer …, 2022 - AACR
… Prior clinical studies have demonstrated HR+ breast cancers with mutations in either
exon 9 or exon 20 exhibited decreased response to ET (4). To address this clinically, several …
exon 9 or exon 20 exhibited decreased response to ET (4). To address this clinically, several …
Clinical outcome in 23 dogs with exocrine pancreatic carcinoma
CJ Pinard, SE Hocker… - Veterinary and …, 2021 - Wiley Online Library
… generally poor prognosis and clinical outcome. Additionally, the … Mutations in exons 12 and
13 of the KRAS gene have not … Diagnosis of pancreatic carcinoma was routinely made either …
13 of the KRAS gene have not … Diagnosis of pancreatic carcinoma was routinely made either …
[HTML][HTML] Newborn screening of duchenne muscular dystrophy specifically targeting deletions amenable to exon-skipping therapy
P Beckers, JH Caberg, V Dideberg, T Dangouloff… - Scientific Reports, 2021 - nature.com
… DMD patients eligible for either exon-51, exon-53 or exon-45 skipping treatments account …
DMD patients are not eligible for either exon-51, exon-53, or exon-45 skipping therapies and …
DMD patients are not eligible for either exon-51, exon-53, or exon-45 skipping therapies and …
[HTML][HTML] Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer
… Clinical outcomes of NSCLC patients with rare EGFR mutations in exon 18 after EGFRi …
complex EGFR mutations that contained either exon 20 insertions or T790M mutations [79]. …
complex EGFR mutations that contained either exon 20 insertions or T790M mutations [79]. …