Clinical Outcomes in Patients with Multi-Hit TP53 Chronic Lymphocytic Leukemia Treated with Ibrutinib

C Brieghel, K Aarup, MH Torp, MA Andersen… - Clinical Cancer …, 2021 - AACR
… to investigate clinical outcomes in 51 patients treated with ibrutinib carrying either a single …
initiation of ibrutinib for mutations in the TP53 gene (exons 2–10 +2 base-pair intronic overlap) …

[HTML][HTML] Germline cancer susceptibility gene testing in unselected patients with colorectal adenocarcinoma: a multicenter prospective study

PLS Uson Jr, D Riegert-Johnson, L Boardman… - Clinical …, 2022 - Elsevier
… approach, association with clinical outcomes, and the uptake of family variant testing. … coding
exons, 10–20 base pairs of adjacent intronic sequencing on either side of the coding exons

Pretransplant FLT3-ITD MRD assessed by high-sensitivity PCR-NGS determines posttransplant clinical outcome

S Loo, R Dillon, A Ivey, NS Anstee… - Blood, The Journal …, 2022 - ashpublications.org
… Amplicon-based PCR-NGS of exons 14 to 15 detected FLT3-ITDs of at least 6 base pairs to
a … Interestingly, intermediate RFS and OS were observed for patients positive for either NPM1 …

HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

Y Zaimoku, BA Patel, SD Adams… - Blood, The Journal …, 2021 - ashpublications.org
… HLA-A and 2 mutations in cytoplasmic tail (exon 7) of HLA-C (… least 2 years before the clinical
diagnosis of clonal evolution … expand and become clinically evident, either by accumulating …

NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes

A Singh, A Daemen, D Nickles, SM Jeon… - Clinical Cancer …, 2021 - AACR
… encoding CMV-Cre-recombinase to delete exons 2–3 of Keap1 and exons 3–6 of Stk11 in
the … were only upregulated in clinical samples, suggesting they may either represent context-…

Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck

A Agaimy, JK Dermawan, I Leong… - Genes …, 2022 - Wiley Online Library
… All VGLL3 fusions were in-frame and involved exon 2, fused with either TCF12 exon 16,
EP300 exon 31, or PPARGC1A exon 5, respectively. This series characterizes a distinctive …

Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant

SM Tolaney, M Toi, P Neven, J Sohn, EM Grischke… - Clinical Cancer …, 2022 - AACR
… Prior clinical studies have demonstrated HR+ breast cancers with mutations in either
exon 9 or exon 20 exhibited decreased response to ET (4). To address this clinically, several …

Clinical outcome in 23 dogs with exocrine pancreatic carcinoma

CJ Pinard, SE Hocker… - Veterinary and …, 2021 - Wiley Online Library
… generally poor prognosis and clinical outcome. Additionally, the … Mutations in exons 12 and
13 of the KRAS gene have not … Diagnosis of pancreatic carcinoma was routinely made either

[HTML][HTML] Newborn screening of duchenne muscular dystrophy specifically targeting deletions amenable to exon-skipping therapy

P Beckers, JH Caberg, V Dideberg, T Dangouloff… - Scientific Reports, 2021 - nature.com
… DMD patients eligible for either exon-51, exon-53 or exon-45 skipping treatments account …
DMD patients are not eligible for either exon-51, exon-53, or exon-45 skipping therapies and …

[HTML][HTML] Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer

PT Harrison, S Vyse, PH Huang - Seminars in cancer biology, 2020 - Elsevier
Clinical outcomes of NSCLC patients with rare EGFR mutations in exon 18 after EGFRi …
complex EGFR mutations that contained either exon 20 insertions or T790M mutations [79]. …