Prospective evaluation of the utility of whole exome sequencing in dilated cardiomyopathy

J Ramchand, M Wallis, I Macciocca… - Journal of the …, 2020 - Am Heart Assoc
… We recruited patients with idiopathic DCM who were either (1) … ‐specific exons or other
infrequently used TTN exons were … Adverse clinical outcomes such as heart failure hospitalization…

Retrospective Case Series Analysis of RAF Family Alterations in Pancreatic Cancer: Real-World Outcomes From Targeted and Standard Therapies

A Hendifar, EM Blais, B Wolpin, V Subbiah… - JCO precision …, 2021 - ascopubs.org
… -altered PC including clinical outcomes on MAPK pathway … and encouraging outcomes in
patients within BRAF Exon 15 … significant for either RAF subgroups (A) Exon 15, (B) Exon 11…

Artificial intelligence-based prediction of clinical outcome in immunotherapy and targeted therapy of lung cancer

X Yin, H Liao, H Yun, N Lin, S Li, Y Xiang… - Seminars in cancer biology, 2022 - Elsevier
… -TKIs can be applied in NSCLC patients with either EGFR exon 19 del or exon 21
Leu858Arg point mutations, although they showed better responses in exon 19 del patients [103]. …

[HTML][HTML] Molecular characterization and clinical outcomes in RET-rearranged NSCLC

AC Tan, AOL Seet, GGY Lai, TH Lim, AST Lim… - Journal of Thoracic …, 2020 - Elsevier
… , consisting of RET rearrangements identified by either FISH or NGS testing. For patients …
or equal to 15% of tumor cells positive with either split signals or isolated 3′ probes for RET…

Characteristics and outcomes of patients with RET-fusion positive non-small lung cancer in real-world practice in the United States

LM Hess, Y Han, YE Zhu, NR Bhandari, A Sireci - BMC cancer, 2021 - Springer
… the baseline characteristics and clinical outcomes among patients … as either positive or
negative by abstractors using either … Two patients with RET fusions had an exon 19 mutation (one …

Clinical implications of germline BCL2L11 deletion polymorphism in pretreated advanced NSCLC patients with osimertinib therapy

X Li, D Zhang, B Li, B Zou, S Wang, B Fan, W Li, J Yu… - Lung Cancer, 2021 - Elsevier
… Cox proportional hazards models were used to analyze the clinical outcomes of patients …
osimertinib has shown significant clinical efficacy in NSCLC patients with either EGFR-sensitive …

Gene expression profiling of PDGFRA mutant GIST reveals immune signatures as a specific fingerprint of D842V exon 18 mutation

V Indio, G Ravegnini, A Astolfi, M Urbini… - Frontiers in …, 2020 - frontiersin.org
… GIST patients either carrying a genomic alteration on exon 18 D842V (… exon 12 V561D,
exon 14 K646E) and three patients showing insertions/deletions (indel) either in exon 12 or exon

Updated overall survival in a randomized study comparing dacomitinib with gefitinib as first-line treatment in patients with advanced non-small-cell lung cancer and …

TS Mok, Y Cheng, X Zhou, KH Lee, K Nakagawa… - Drugs, 2021 - Springer
… diagnosed NSCLC and EGFR mutation (exon 19 deletion or exon 21 L858R substitution),
and … In the FLAURA trial comparing patients treated with either osimertinib (n = 279) or a first-…

Crizotinib in MET exon 14-mutated or MET-amplified in advanced disease non-small cell lung cancer: a retrospective, single institution experience

W Shalata, A Yakobson, S Weissmann, E Oscar… - Oncology, 2022 - karger.com
… diagnosed with different stages of NSCLC, having either a c-MET exon 14 skipping mutation
or an … Crizotinib was found to be an optimal treatment for NSCLC harboring c-MET exon 14 …

Genotype–phenotype correlations in Duchenne and Becker muscular dystrophy patients from the Canadian neuromuscular disease registry

KRQ Lim, Q Nguyen, T Yokota - Journal of Personalized Medicine, 2020 - mdpi.com
… Of the 238 DMD patients in our cohort with deletion mutations not involving either exon 1 or
79… For clinical outcomes, we looked at wheelchair use (combined permanent and intermittent …