… In this study of KRAS-mutant lung cancer models, combining MEK inhibition with
immunotherapies such as anti-PD-1 or anti-PD-L1 antibodies showed a synergistic effect and …

… resistance, combination therapy targeting BRAF and MEK, a … BRAF and MEK inhibitor
combinations have been approved … for various BRAF plus MEK combination regimens in three …

… Here, we provide preclinical rationale and clinical trial data for combined RAF and MEK
inhibition against tumors with activated non-V600 BRAF mutants. While the combination had a …

… A rationally designed combination of RAF and MEK inhibitors based on their conformation
selectivity achieved increased efficacy and a high therapeutic index when used to target …

… to RAF and MEK inhibitor therapy [57]. Combined YAP and RAF or MEK inhibition was …
a biomarker of worse initial response to RAF and MEK inhibition in patients, indicating the …

… , 3 have had a prior MEK inhibitor and are currently are on … of the combination of a RAF-MEK
and FAK inhibitor with very … those who had been previously treated with a MEK inhibitor. …

… MEK inhibitor (MEKi) monotherapy provides limited clinical benefits but may serve as a
foundation for combination therapies. Here, we showed that combining a type II RAF inhibitor (…

… by MEK inhibitors and enhances sensitivity of KRAS-dependent cancers to MEK inhibition, …
Our data provide strong evidence that combined SOS1 and MEK inhibition represents an …

… We observed enhanced antitumor efficacy for RAF dimer and MEK inhibitor combination, …
reports suggesting RAF dimer or pan-RAF inhibitor in combination with MEK inhibitor may be a …

… Recently, MEK inhibitors have shown an overall response rate (ORR) 15-26%. Activation …
MEK inhibitors and we hypothesised combination of a RAF/MEK inhibitor with a FAK inhibitor …