Phenotypic plasticity: from theory and genetics to current and future challenges
RJ Sommer - Genetics, 2020 - academic.oup.com
… other examples of plasticity also involve complex switch mechanisms. For example, the …
example of phenotypic plasticity in nematodes, is also regulated in a complex manner and …
example of phenotypic plasticity in nematodes, is also regulated in a complex manner and …
Phenotypic plasticity under rapid global changes: The intrinsic force for future seagrasses survival
… phenotypic plasticity and the possibility that such plastic responses might or might not be
adaptive is complex… Another important way forward is the integration of different phenotypic and …
adaptive is complex… Another important way forward is the integration of different phenotypic and …
[HTML][HTML] The phenotypic landscape of essential human genes
… Analysis of >31 million individual cells identified measurable phenotypes for >90% of gene
knockouts, implicating gene targets in specific cellular processes. Clustering of phenotypic …
knockouts, implicating gene targets in specific cellular processes. Clustering of phenotypic …
A complex systems approach to aging biology
… accomplished by the integration of regulatory mechanisms at multiple hierarchical scales,
and that the disruption of this ensemble causes the phenotypic and functional manifestations …
and that the disruption of this ensemble causes the phenotypic and functional manifestations …
Characterizing long COVID: deep phenotype of a complex condition
… questions, this analysis documented 205 phenotypic features associated with long COVID.
… phenotyping that enables integrated computational analysis of genotype and phenotype for …
… phenotyping that enables integrated computational analysis of genotype and phenotype for …
Multi-omics integration in biomedical research–A metabolomics-centric review
… large-scale integration efforts aiming at a global depiction of the complex relationships
within and between different biological layers without focusing on a particular phenotype. …
within and between different biological layers without focusing on a particular phenotype. …
Computational principles and challenges in single-cell data integration
… have limited capacity to discover complex molecular maps resulting from interactions between
multiple genomic features. An alternative strategy for data integration is to exploit the full …
multiple genomic features. An alternative strategy for data integration is to exploit the full …
Environmental change and the evolution of genomes: Transposable elements as translators of phenotypic plasticity into genotypic variability
S Pimpinelli, L Piacentini - Functional Ecology, 2020 - Wiley Online Library
… Six different integrated molecular mechanisms can affect the epigenome in response to …
, remodelling by chromatin-remodelling complexes, incorporation of histone variants and the …
, remodelling by chromatin-remodelling complexes, incorporation of histone variants and the …
Heterogeneous multi-layered network model for omics data integration and analysis
… Thirdly, we demonstrate their applications to omics data integration and analysis. Finally,
we outline strategies for future directions in the development of new HMLN models. …
we outline strategies for future directions in the development of new HMLN models. …
Identifying genetic variants underlying phenotypic variation in plants without complete genomes
Structural variants and presence/absence polymorphisms are common in plant genomes,
yet they are routinely overlooked in genome-wide association studies (GWAS). Here, we …
yet they are routinely overlooked in genome-wide association studies (GWAS). Here, we …