Phenotypic plasticity: from theory and genetics to current and future challenges

RJ Sommer - Genetics, 2020 - academic.oup.com
… other examples of plasticity also involve complex switch mechanisms. For example, the …
example of phenotypic plasticity in nematodes, is also regulated in a complex manner and …

Phenotypic plasticity under rapid global changes: The intrinsic force for future seagrasses survival

J Pazzaglia, TBH Reusch, A Terlizzi… - Evolutionary …, 2021 - Wiley Online Library
phenotypic plasticity and the possibility that such plastic responses might or might not be
adaptive is complex… Another important way forward is the integration of different phenotypic and …

[HTML][HTML] The phenotypic landscape of essential human genes

L Funk, KC Su, J Ly, D Feldman, A Singh, B Moodie… - Cell, 2022 - cell.com
… Analysis of >31 million individual cells identified measurable phenotypes for >90% of gene
knockouts, implicating gene targets in specific cellular processes. Clustering of phenotypic

A complex systems approach to aging biology

AA Cohen, L Ferrucci, T Fülöp, D Gravel, N Hao… - Nature Aging, 2022 - nature.com
… accomplished by the integration of regulatory mechanisms at multiple hierarchical scales,
and that the disruption of this ensemble causes the phenotypic and functional manifestations …

Characterizing long COVID: deep phenotype of a complex condition

RR Deer, MA Rock, N Vasilevsky, L Carmody… - …, 2021 - thelancet.com
… questions, this analysis documented 205 phenotypic features associated with long COVID.
phenotyping that enables integrated computational analysis of genotype and phenotype for …

Multi-omics integration in biomedical research–A metabolomics-centric review

MA Wörheide, J Krumsiek, G Kastenmüller… - Analytica chimica …, 2021 - Elsevier
… large-scale integration efforts aiming at a global depiction of the complex relationships
within and between different biological layers without focusing on a particular phenotype. …

Computational principles and challenges in single-cell data integration

R Argelaguet, ASE Cuomo, O Stegle… - Nature biotechnology, 2021 - nature.com
… have limited capacity to discover complex molecular maps resulting from interactions between
multiple genomic features. An alternative strategy for data integration is to exploit the full …

Environmental change and the evolution of genomes: Transposable elements as translators of phenotypic plasticity into genotypic variability

S Pimpinelli, L Piacentini - Functional Ecology, 2020 - Wiley Online Library
… Six different integrated molecular mechanisms can affect the epigenome in response to …
, remodelling by chromatin-remodelling complexes, incorporation of histone variants and the …

Heterogeneous multi-layered network model for omics data integration and analysis

B Lee, S Zhang, A Poleksic, L Xie - Frontiers in genetics, 2020 - frontiersin.org
… Thirdly, we demonstrate their applications to omics data integration and analysis. Finally,
we outline strategies for future directions in the development of new HMLN models. …

Identifying genetic variants underlying phenotypic variation in plants without complete genomes

Y Voichek, D Weigel - Nature genetics, 2020 - nature.com
Structural variants and presence/absence polymorphisms are common in plant genomes,
yet they are routinely overlooked in genome-wide association studies (GWAS). Here, we …