Spinal cord injury and loss of cortical inhibition
B Benedetti, A Weidenhammer, M Reisinger… - International Journal of …, 2022 - mdpi.com
… Furthermore, some works have provided evidence against cortical disinhibition and in
favor of increased corticospinal inhibition when using paired-pulse TMS and comparing SCI …
favor of increased corticospinal inhibition when using paired-pulse TMS and comparing SCI …
Corticospinal inhibition investigated in relation to upper extremity motor function in cervical spinal cord injury
… Corticospinal inhibitory mechanisms are relevant to functional recovery but remain poorly
understood after spinal cord injury (SCI). Post-injury characteristics of contralateral silent …
understood after spinal cord injury (SCI). Post-injury characteristics of contralateral silent …
Corticospinal motor circuit plasticity after spinal cord injury: harnessing neuroplasticity to improve functional outcomes
… of corticospinal motor circuitry after SCI. Lastly, will review the potential therapeutic strategies
targeting neuroplasticity in the corticospinal motor circuit for functional recovery after SCI. …
targeting neuroplasticity in the corticospinal motor circuit for functional recovery after SCI. …
… training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice
L Pan, B Tan, W Tang, M Luo, Y Liu, L Yu… - Behavioural brain …, 2021 - Elsevier
… We found that only PTEN-inhibited corticospinal neurons had p-S6 over expression. In
contrast, expression of p-S6 in the Control group and the Control + TR group remained …
contrast, expression of p-S6 in the Control group and the Control + TR group remained …
Modulation of both intrinsic and extrinsic factors additively promotes rewiring of corticospinal circuits after spinal cord injury
Y Nakamura, M Ueno, JK Niehaus… - Journal of …, 2021 - Soc Neuroscience
… of extrinsic inhibitory … of injured corticospinal neurons after SCI. Because of the variety of
growth-restrictive extrinsic molecules, it remains unclear how inhibition of conserved inhibitory …
growth-restrictive extrinsic molecules, it remains unclear how inhibition of conserved inhibitory …
Do spinal circuits still require gating of sensory information by presynaptic inhibition after spinal cord injury?
NR Lalonde, TV Bui - Current Opinion in Physiology, 2021 - Elsevier
… including descending structures such as corticospinal, reticulospinal, vestibulospinal, and
rubrospinal descending fibres [16,17], as well as neuromodulatory [18] and intraspinal circuits …
rubrospinal descending fibres [16,17], as well as neuromodulatory [18] and intraspinal circuits …
Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury
… of exercise combined with paired corticospinal-motor neuronal stimulation (… cord injury
with similar characteristics. During PCMS, 180 pairs of stimuli were timed to have corticospinal …
with similar characteristics. During PCMS, 180 pairs of stimuli were timed to have corticospinal …
Global disinhibition and corticospinal plasticity for drastic recovery after spinal cord injury
R Yamaguchi, S Ueno, T Kawasaki, ZC Chao… - bioRxiv, 2023 - biorxiv.org
… The interhemispheric inhibition observed before injury was switched to … cord injury or stroke
(1–3). In a nonhuman primate model of partial spinal cord injury targeting the corticospinal …
(1–3). In a nonhuman primate model of partial spinal cord injury targeting the corticospinal …
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury
W Sun, MJE Larson, CM Kiyoshi… - The Journal of …, 2020 - Am Soc Clin Investig
… Several strategies have recently challenged this notion by reprogramming the deficient
intrinsic growth state of adult neurons and eliminating extracellular growth inhibitors, triggering …
intrinsic growth state of adult neurons and eliminating extracellular growth inhibitors, triggering …
… facilitation of the spinal locomotor central pattern generator and reflex circuits by somatosensory feedback from the lumbar and perineal regions after spinal cord injury
AN Merlet, J Harnie, A Frigon - Frontiers in Neuroscience, 2021 - frontiersin.org
… cord injury and the possible mechanisms involved. We also discuss how spinal cord injury
can … and withdrawal of corticospinal axons. In contrast, dorsal roots sections led to increased …
can … and withdrawal of corticospinal axons. In contrast, dorsal roots sections led to increased …
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