Spinal cord injury and loss of cortical inhibition

B Benedetti, A Weidenhammer, M Reisinger… - International Journal of …, 2022 - mdpi.com
… Furthermore, some works have provided evidence against cortical disinhibition and in
favor of increased corticospinal inhibition when using paired-pulse TMS and comparing SCI …

Corticospinal inhibition investigated in relation to upper extremity motor function in cervical spinal cord injury

T Arora, J Liu, A Mohan, X Li, K O'laughlin… - Clinical …, 2024 - Elsevier
Corticospinal inhibitory mechanisms are relevant to functional recovery but remain poorly
understood after spinal cord injury (SCI). Post-injury characteristics of contralateral silent …

Corticospinal motor circuit plasticity after spinal cord injury: harnessing neuroplasticity to improve functional outcomes

SF Kazim, CA Bowers, CD Cole, S Varela… - Molecular …, 2021 - Springer
… of corticospinal motor circuitry after SCI. Lastly, will review the potential therapeutic strategies
targeting neuroplasticity in the corticospinal motor circuit for functional recovery after SCI. …

… training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice

L Pan, B Tan, W Tang, M Luo, Y Liu, L Yu… - Behavioural brain …, 2021 - Elsevier
… We found that only PTEN-inhibited corticospinal neurons had p-S6 over expression. In
contrast, expression of p-S6 in the Control group and the Control + TR group remained …

Modulation of both intrinsic and extrinsic factors additively promotes rewiring of corticospinal circuits after spinal cord injury

Y Nakamura, M Ueno, JK Niehaus… - Journal of …, 2021 - Soc Neuroscience
… of extrinsic inhibitory … of injured corticospinal neurons after SCI. Because of the variety of
growth-restrictive extrinsic molecules, it remains unclear how inhibition of conserved inhibitory

Do spinal circuits still require gating of sensory information by presynaptic inhibition after spinal cord injury?

NR Lalonde, TV Bui - Current Opinion in Physiology, 2021 - Elsevier
… including descending structures such as corticospinal, reticulospinal, vestibulospinal, and
rubrospinal descending fibres [16,17], as well as neuromodulatory [18] and intraspinal circuits …

Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury

HJ Jo, MA Perez - Brain, 2020 - academic.oup.com
… of exercise combined with paired corticospinal-motor neuronal stimulation (… cord injury
with similar characteristics. During PCMS, 180 pairs of stimuli were timed to have corticospinal

Global disinhibition and corticospinal plasticity for drastic recovery after spinal cord injury

R Yamaguchi, S Ueno, T Kawasaki, ZC Chao… - bioRxiv, 2023 - biorxiv.org
… The interhemispheric inhibition observed before injury was switched to … cord injury or stroke
(1–3). In a nonhuman primate model of partial spinal cord injury targeting the corticospinal

Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury

W Sun, MJE Larson, CM Kiyoshi… - The Journal of …, 2020 - Am Soc Clin Investig
… Several strategies have recently challenged this notion by reprogramming the deficient
intrinsic growth state of adult neurons and eliminating extracellular growth inhibitors, triggering …

… facilitation of the spinal locomotor central pattern generator and reflex circuits by somatosensory feedback from the lumbar and perineal regions after spinal cord injury

AN Merlet, J Harnie, A Frigon - Frontiers in Neuroscience, 2021 - frontiersin.org
cord injury and the possible mechanisms involved. We also discuss how spinal cord injury
can … and withdrawal of corticospinal axons. In contrast, dorsal roots sections led to increased …