[HTML][HTML] Core proteome mediated therapeutic target mining and multi-epitope vaccine design for Helicobacter pylori

N Rahman, A Ajmal, F Ali, L Rastrelli - Genomics, 2020 - Elsevier
… this has been used for drug target mining in many pathogens like … genomics approach was
used to identify novel, essential, and human non-homologous drug as well as vaccine targets

[HTML][HTML] Integrated core proteomics, subtractive proteomics, and immunoinformatics investigation to unveil a potential multi-epitope vaccine against schistosomiasis

A Rehman, S Ahmad, F Shahid, A Albutti… - Vaccines, 2021 - mdpi.com
… The pipeline revealed two antigenic proteins—calcium binding and mycosubtilin synthase
subunit C—as promising vaccine targets. T and B cell epitopes from the targeted proteins …

[HTML][HTML] … of Putative Vaccine and Drug Targets against the Methicillin-Resistant Staphylococcus aureus by Reverse Vaccinology and Subtractive Genomics …

RS Naorem, BD Pangabam, SS Bora, G Goswami… - Molecules, 2022 - mdpi.com
vaccine candidates and drug target proteins against the 16 strains of MRSA using reverse
vaccinology and subtractive genomics … The essential core proteome that has homology among …

[HTML][HTML] Chimeric vaccine designs against Acinetobacter baumannii using pan genome and reverse vaccinology approaches

F Shahid, T Zaheer, ST Ashraf, M Shehroz, F Anwer… - Scientific reports, 2021 - nature.com
… In this study the in-house pipeline PanRV was used to filter out the core genome targets
along with separate sequential filtering to double check the ambiguous results. The …

[HTML][HTML] Coronavirus pandemic—therapy and vaccines

K Lundstrom - Biomedicines, 2020 - mdpi.com
genomic composition of SARS-CoV-2 and its lifecycle to identify potential drug and vaccine
targets… heat-labile enterotoxin B (LTB) and the core neutralizing epitope (COE) of PEDV was …

[HTML][HTML] In silico functional prediction of hypothetical proteins from the core genome of Corynebacterium pseudotuberculosis biovar ovis

CL Araújo, I Blanco, L Souza, S Tiwari, LC Pereira… - PeerJ, 2020 - peerj.com
targets, specially to investigate the role of these products in vitro, as well as their potential
to be involved in pathogenesis and its use for the development of new therapeutic targets

[HTML][HTML] Vaccinomics to Design a Multi-Epitopes Vaccine for Acinetobacter baumannii

M Ud-Din, A Albutti, A Ullah, S Ismail, S Ahmad… - International Journal of …, 2022 - mdpi.com
… proteins are not part of the core genome and are poor immunological targets [33]. On the
other hand, non-redundant proteins are good vaccine candidates because they are present in …

Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines

L He, N Tzarum, X Lin, B Shapero, C Sou, CJ Mann… - Science …, 2020 - science.org
… These general design principles and nanoparticle platforms can, in principle, be applied
to a wide range of vaccine targets including HCV. Epitope scaffolds have been designed for …

Immunoinformatics and vaccine development: an overview

AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
genomes for possible vaccine target. With these tools, many proteins of virulence interest can
be sequenced and the most essential gene of interest modeled for a potential vaccinecore

Current status of pan-genome analysis for pathogenic bacteria

Y Kim, C Gu, HU Kim, SY Lee - Current opinion in biotechnology, 2020 - Elsevier
Core genome is a set of gene families that are shared by all genomes of a target clade, which
… for possible discovery and development of vaccines and new drugs. Taken together, pan-…