Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
… x-ray crystal structures in two different crystal forms, at 1.95 and 2.20 Å resolution, of the
complex between α-ketoamide 13b and the M pro of SARS-CoV-2. One structure is in space …
complex between α-ketoamide 13b and the M pro of SARS-CoV-2. One structure is in space …
Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
Y Kim, R Jedrzejczak, NI Maltseva… - Protein …, 2020 - Wiley Online Library
… We compare these structures with previously reported homologs from SARS … crystal structures
of SARS-CoV-2 Nsp15 determined at 1.90 Å and 2.20 Å resolution. The Nsp15 structure is …
of SARS-CoV-2 Nsp15 determined at 1.90 Å and 2.20 Å resolution. The Nsp15 structure is …
Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9
… We sought to better characterize the SARS-CoV-2 Nsp9 and subsequently solved its X-ray
crystal structure, in an apo form and, unexpectedly, in a peptide-bound form with a sequence …
crystal structure, in an apo form and, unexpectedly, in a peptide-bound form with a sequence …
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site
J Lee, LJ Worrall, M Vuckovic, FI Rosell… - Nature …, 2020 - nature.com
… We have determined X-ray crystallographic structures of this cysteine protease in its wild-type
free active site state at 1.8 Å resolution, in its acyl-enzyme intermediate state with the …
free active site state at 1.8 Å resolution, in its acyl-enzyme intermediate state with the …
Accurate crystal structures and chemical properties from NoSpherA2
…, JL Spencer, F White, B Grundkötter-Stock… - Chemical …, 2021 - pubs.rsc.org
… This model building is central to any technique based on diffraction, and it is this final model
that we call a ‘crystal structure’. Calculating the expected diffraction pattern from this model …
that we call a ‘crystal structure’. Calculating the expected diffraction pattern from this model …
Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor
J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - BioRxiv, 2020 - biorxiv.org
… To better understand the initial step of infection at atomic-level, we determined the crystal
structure of the 2019-nCoV spike receptor-binding domain (RBD) bound with the cell receptor …
structure of the 2019-nCoV spike receptor-binding domain (RBD) bound with the cell receptor …
Changes in the crystallinity degree of starch having different types of crystal structure after mechanical pretreatment
K Dome, E Podgorbunskikh, A Bychkov, O Lomovsky - Polymers, 2020 - mdpi.com
… The aim of this study was to investigate disordering of the crystalline structure of starch in
three different polymorphic modifications caused by mechanical activation. The regularities “…
three different polymorphic modifications caused by mechanical activation. The regularities “…
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
Y Zhao, C Fang, Q Zhang, R Zhang, X Zhao, Y Duan… - Protein & cell, 2022 - Springer
… In conclusion, the 1.6-Å crystal structure of SARS-CoV-2 M pro in complex with the protease
inhibitor PF-07321332 reveals critical insight for pharmaceutical development. With the …
inhibitor PF-07321332 reveals critical insight for pharmaceutical development. With the …
[HTML][HTML] Crystal structure of SARS-CoV-2 papain-like protease
X Gao, B Qin, P Chen, K Zhu, P Hou, JA Wojdyla… - … Pharmaceutica Sinica B, 2021 - Elsevier
… Here, we determined the crystal structure of the unliganded SARS-CoV-2 PLpro exhibiting
unique crystal packing, high solvent content and reasonable resolution, suggesting this …
unique crystal packing, high solvent content and reasonable resolution, suggesting this …
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
… We determined crystal structures of two of these inhibitors in complex with SARS-CoV-2 …
K48-linked Ub chains is diminished, which our sequence and structure analysis provides a …
K48-linked Ub chains is diminished, which our sequence and structure analysis provides a …
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