Zebrafish heart failure models

S Narumanchi, H Wang, S Perttunen… - … and developmental …, 2021 - frontiersin.org
… and CRISPR-Cas9 to modulate gene function, make zebrafish a primary animal model for in
… of developmental disorders may be investigated with embryonic zebrafish. Some autosomal-…

Developmental stages of zebrafish (Danio rerio) embryos and toxicological studies using foldscope microscope

BV Yesudhason, JRS Selvan Christyraj… - Cell Biology …, 2020 - Wiley Online Library
… In addition, the genome has numerous orthologs and analogous gene, which is mutated
in neurodegenerative studies, such as alzheimer's disease, Parkinson disease, etc (Dorszewska…

The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish

J Zhu, HT Wang, YR Chen, LY Yan, YY Han, LY Liu… - Neuroscience …, 2020 - Springer
… The developmental stages of zebrafish were characterized following previously-described
morphological criteria [11]. Fish embryos and larvae for in situ hybridization and …

Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes

Y Wang, Z Liu, G Yang, Q Gao, L Xiao, J Li… - … and developmental …, 2020 - frontiersin.org
… We screened these gene families by comparing our candidate gene list with IS candidate
genes in the Human Phenotype Ontology (HPO) database and previous reported studies. Two …

Zebrafish: a model organism for studying enteric nervous system development and disease

LE Kuil, RK Chauhan, WW Cheng… - … and Developmental …, 2021 - frontiersin.org
… in gene editing techniques and their unique properties, research using zebrafish as a …
The zebrafish genome has been sequenced, is well annotated and around 71.4% of human …

Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development

XR Dong, SM Wan, JJ Zhou, CH Nie… - … and Developmental …, 2022 - frontiersin.org
… Using the β-actin gene of zebrafish as a reference gene, we used the comparative 2 −△△Ct
method to determine the relative gene expression between the wild types and mutants (…

In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs

JH Westhoff, PJ Steenbergen, LSV Thomas… - … and developmental …, 2020 - frontiersin.org
… To score developmental phenotypes of the zebrafish developing … in live zebrafish embryos
and larvae (Westhoff et al., 2013). In a pilot screen, we could show that human developmental

Antisense RNAs during early vertebrate development are divided in groups with distinct features

S Pillay, H Takahashi, P Carninci… - Genome Research, 2021 - genome.cshlp.org
… early zebrafish developmental stages spanning MZT. The aim of this study is to identify
distinct features of … and in predicting their function in regulating sense-strand gene expression. …

Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility

HJ Lee, Y Hou, Y Chen, ZZ Dailey, A Riddihough… - Genome biology, 2020 - Springer
… The mutant zebrafish did not show any abnormal developmental or morphological phenotypes
and were able to fully regrow their regenerates in 3 weeks, suggesting that the delayed …

Mechanistic Insights into Axenfeld–Rieger Syndrome from Zebrafish foxc1 and pitx2 Mutants

CR French - International Journal of Molecular Sciences, 2021 - mdpi.com
… of developmental phenotypes. This review summarizes the published phenotypes in zebrafish
foxc1 … The zebrafish genome contains a single pitx2 gene that encodes two isoforms via …