Metabolomics and proteomics in type 2 diabetes
ZZ Chen, RE Gerszten - Circulation research, 2020 - Am Heart Assoc
… a high-fat diet, and diabetic rats. Also, … Changes in metabolites including betaine, due to
changes in physical activity and diet, 136 and arginine and arginine metabolites, due to changes …
changes in physical activity and diet, 136 and arginine and arginine metabolites, due to changes …
Quantitative comparative proteomics reveals candidate biomarkers for the early prediction of gestational diabetes mellitus: a preliminary study
… non-diabetic ones were analyzed using isobaric tag for relative and absolute quantitation –
labeled proteomics. … Conclusion: The reported plasma proteomic changes represent potential …
labeled proteomics. … Conclusion: The reported plasma proteomic changes represent potential …
[HTML][HTML] Hepatic proteomic changes and Sirt1/AMPK signaling activation by oxymatrine treatment in rats with non-alcoholic steatosis
H Xu, GF Chen, YS Ma, HW Zhang, Y Zhou… - Frontiers in …, 2020 - frontiersin.org
… In this study, by using iTRAQ-based proteomic method, a bunch of DEPs which up-regulate
or down-regulate significantly by OMT treatment were identified. The data of GO analysis …
or down-regulate significantly by OMT treatment were identified. The data of GO analysis …
Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies
J Diniz Pereira, V Gomes Fraga… - Journal of …, 2021 - Wiley Online Library
… Several studies have used proteomic techniques in order … proteomic profile in diabetic
patients with AD. Therefore, this study aimed to systematically review the studies using proteomic …
patients with AD. Therefore, this study aimed to systematically review the studies using proteomic …
Application of Proteomics and Machine Learning Methods to Study the Pathogenesis of Diabetic Nephropathy and Screen Urinary Biomarkers
X Yan, X Zhang, H Li, Y Zou, W Lu… - Journal of Proteome …, 2024 - ACS Publications
… proteomics technology to detect changes in differential expression of urinary proteins in type
2 diabetes … (72,73) NG2 is upregulated in the kidney of diabetic rats and has been shown to …
2 diabetes … (72,73) NG2 is upregulated in the kidney of diabetic rats and has been shown to …
[HTML][HTML] Differential urinary proteome analysis for predicting prognosis in type 2 diabetes patients with and without renal dysfunction
… rat glomerular transcriptome profiling, it was confirmed that GM2A was highly expressed in
various diabetic kidney disease rat … mRNA expression was not changed in the acute phase, …
various diabetic kidney disease rat … mRNA expression was not changed in the acute phase, …
Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus
… , non-diabetic controls. In order to explore the mechanisms causing changes in gene
expression, … biological insight into the observed expression changes. The essential top upstream …
expression, … biological insight into the observed expression changes. The essential top upstream …
[HTML][HTML] LC-MS-Based untargeted metabolomics reveals early biomarkers in STZ-induced diabetic rats with cognitive impairment
R Chen, Y Zeng, W Xiao, L Zhang, Y Shu - Frontiers in endocrinology, 2021 - frontiersin.org
… changes of disease-specific metabolites in biological samples (5). Compared with proteomics
… is very helpful for discovering the pathophysiological changes of cells, body fluids, and …
… is very helpful for discovering the pathophysiological changes of cells, body fluids, and …
[HTML][HTML] Proteomics and phosphoproteomics of circulating extracellular vesicles provide new insights into diabetes pathobiology
… proteomic and phosphoproteomic signatures in people with prediabetes and T2DM and
provides novel insight into the pathobiology of diabetes. … that no significant changes occur in the …
provides novel insight into the pathobiology of diabetes. … that no significant changes occur in the …
Deciphering the plasma proteome of type 2 diabetes
… Our prediction models do not reflect the dynamic changes in the proteome, which would
require a more detailed investigation. This is also true for the MR results, which reflect the …
require a more detailed investigation. This is also true for the MR results, which reflect the …
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