Metabolomics and proteomics in type 2 diabetes

ZZ Chen, RE Gerszten - Circulation research, 2020 - Am Heart Assoc
… a high-fat diet, and diabetic rats. Also, … Changes in metabolites including betaine, due to
changes in physical activity and diet, 136 and arginine and arginine metabolites, due to changes

Quantitative comparative proteomics reveals candidate biomarkers for the early prediction of gestational diabetes mellitus: a preliminary study

D Mavreli, N Evangelinakis, N Papantoniou, A Kolialexi - in vivo, 2020 - iv.iiarjournals.org
… non-diabetic ones were analyzed using isobaric tag for relative and absolute quantitation –
labeled proteomics. … Conclusion: The reported plasma proteomic changes represent potential …

[HTML][HTML] Hepatic proteomic changes and Sirt1/AMPK signaling activation by oxymatrine treatment in rats with non-alcoholic steatosis

H Xu, GF Chen, YS Ma, HW Zhang, Y Zhou… - Frontiers in …, 2020 - frontiersin.org
… In this study, by using iTRAQ-based proteomic method, a bunch of DEPs which up-regulate
or down-regulate significantly by OMT treatment were identified. The data of GO analysis …

Alzheimer's disease and type 2 diabetes mellitus: A systematic review of proteomic studies

J Diniz Pereira, V Gomes Fraga… - Journal of …, 2021 - Wiley Online Library
… Several studies have used proteomic techniques in order … proteomic profile in diabetic
patients with AD. Therefore, this study aimed to systematically review the studies using proteomic

Application of Proteomics and Machine Learning Methods to Study the Pathogenesis of Diabetic Nephropathy and Screen Urinary Biomarkers

X Yan, X Zhang, H Li, Y Zou, W Lu… - Journal of Proteome …, 2024 - ACS Publications
proteomics technology to detect changes in differential expression of urinary proteins in type
2 diabetes … (72,73) NG2 is upregulated in the kidney of diabetic rats and has been shown to …

[HTML][HTML] Differential urinary proteome analysis for predicting prognosis in type 2 diabetes patients with and without renal dysfunction

HS Ahn, JH Kim, H Jeong, J Yu, J Yeom… - International Journal of …, 2020 - mdpi.com
rat glomerular transcriptome profiling, it was confirmed that GM2A was highly expressed in
various diabetic kidney disease rat … mRNA expression was not changed in the acute phase, …

Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus

AK Cheema, P Kaur, A Fadel, N Younes… - Diabetes, Metabolic …, 2020 - Taylor & Francis
… , non-diabetic controls. In order to explore the mechanisms causing changes in gene
expression, … biological insight into the observed expression changes. The essential top upstream …

[HTML][HTML] LC-MS-Based untargeted metabolomics reveals early biomarkers in STZ-induced diabetic rats with cognitive impairment

R Chen, Y Zeng, W Xiao, L Zhang, Y Shu - Frontiers in endocrinology, 2021 - frontiersin.org
changes of disease-specific metabolites in biological samples (5). Compared with proteomics
… is very helpful for discovering the pathophysiological changes of cells, body fluids, and …

[HTML][HTML] Proteomics and phosphoproteomics of circulating extracellular vesicles provide new insights into diabetes pathobiology

YO Nunez Lopez, A Iliuk, AM Petrilli, C Glass… - International journal of …, 2022 - mdpi.com
proteomic and phosphoproteomic signatures in people with prediabetes and T2DM and
provides novel insight into the pathobiology of diabetes. … that no significant changes occur in the …

Deciphering the plasma proteome of type 2 diabetes

MA Elhadad, C Jonasson, C Huth, R Wilson… - Diabetes, 2020 - Am Diabetes Assoc
… Our prediction models do not reflect the dynamic changes in the proteome, which would
require a more detailed investigation. This is also true for the MR results, which reflect the …