Effects of topical insulin on wound healing: a review of animal and human evidences

J Wang, J Xu - Diabetes, Metabolic Syndrome and Obesity, 2020 - Taylor & Francis
… in control and diabetic rats; the results showed that insulin cream increases inflammatory
cell infiltration, and collagen deposition in diabetic rats, whereas non-diabetic rats show no …

[HTML][HTML] Usage of topical insulin for the treatment of diabetic keratopathy, including corneal epithelial defects

CY Leong, AA Naffi, WHWA Halim… - … Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
… Articles were limited to journal articles with the keywords “topical insulin”, diabetes, and …
diabetic rats without TI. This study also compared 1, 2, or 5 U insulin in healthy and diabetic rats

Wound healing potential of insulin-loaded nanoemulsion with Aloe vera gel in diabetic rats

T Chakraborty, S Gupta, A Nair, S Chauhan… - Journal of Drug Delivery …, 2021 - Elsevier
… of developing a topical gel formulation of Aloe vera with insulin-loaded nanoemulsion and
evaluates its potential for wound healing in diabetic rats. The insulin-loaded nanoemulsion …

[PDF][PDF] Effect of Topical Insulin and Ozonized Cream for the Treatment of Full-thickness Dermal Burn Injuries: A Clinical and Histopathological Study in Diabetic Rats.

GÇA Güngör, Ç Gültekin, A Kükner, İ Etikan… - Pakistan Veterinary …, 2022 - pvj.com.pk
Diabetic wound healing is a major health problem encountered in both human and veterinary
medicine. In this study, 30 Wistar albino rats were experimentally induced diabetesinsulin

Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization

P Yang, X Wang, D Wang, Y Shi… - Journal of cell …, 2020 - journals.biologists.com
… deficiencies in the wound were caused by hyper IDE activity, we investigated IDE and
insulin levels in the diabetic rat model. We found that the elevated activity of IDE could degrade …

[HTML][HTML] Nanocarrier-mediated topical insulin delivery for wound healing

AS Macedo, F Mendes, P Filipe, S Reis, P Fonte - Materials, 2021 - mdpi.com
… and diabetic patients with the administration of topical insulin cream [47]. The study … diabetic
rats treated with and without topical insulin cream, along with non-diabetic rats. Wounds of …

Effects of topical insulin on wound healing: A meta-analysis of animal and clinical studies

H Liu, J Wang, Y Deng, G Zou, J Xu - Endocrine Journal, 2021 - jstage.jst.go.jp
… that the application of topical insulin improves wound … Diabetic rats (ND), and the other
group were diabetic rats (D). The excision wound was 1 × 1 cm on the depilated back of the rats

[HTML][HTML] The efficacy of topical insulin application on rat model with burn wounds treated with adipose-derived stem cells

LC Hermeto, R DeRossi, RJ Oliveira… - … Journal of Burns and …, 2020 - ncbi.nlm.nih.gov
… of the treatments on diabetic rats. It can be stated that topical insulin may have more effect on
… results due to topical insulin administration in burned areas of diabetic rats, but they did not …

The synergistic effect of topical insulin and clindamycin on acute dermal wound healing in rat model: a histological study

M Mirhoseini, MA Kianezhad, B Rezaeipour… - Journal of …, 2021 - Taylor & Francis
… effect of insulin and clindamycin on full-thickness wound healing. In this study, 24 Wistar rats
(… cream accelerated dermal wound healing in the diabetic rat and also indicated that other …

Wound healing treatment using insulin within polymeric nanoparticles in the diabetes animal model

MC Ribeiro, VLR Correa, FKL da Silva… - European Journal of …, 2020 - Elsevier
… to improve wound healing in diabetic rats was tested. The … Considering the benefits of topical
administration of insulin, the goal … on the cutaneous wound healing process in diabetic rats. …