… Heart failure is a clinical syndrome characterized by dyspnea or exertional limitation due to
… filling or ejection of blood or both. HFrEF occurs when the left ventricular ejection fraction (…

Importance Heart failure with preserved ejection fraction (HFpEF), defined as HF with an EF
of 50% or higher at diagnosis, affects approximately 3 million people in the US and up to 32 …

… in heart failure with preserved ejection fraction characterized … in heart failure with reduced
ejection fraction characterized by … in heart failure with mid-range ejection fraction secondary …

… guidelines introduced a third EF category for an EF of 40–49%, defined as heart failure with
… heart failure with reduced EF (HFrEF; defined as EF <40% in this Review) and heart failure …

… Heart failure with preserved ejection fraction (HFpEF) has grown to become the dominant form
of heart failure … be distinguished from heart failure with reduced ejection fraction as well as …

… ejection fraction defines “heart failure with reduced ejection fraction” (HFrEF) as LVEF of <40%,
“heart failure with mildly reduced ejection fraction” (HFmrEF) as 40% ≤ LVEF < normal, …

… β-Blockers (BBs) are mainstay therapy for heart failure with reduced ejection fraction. …
predictor (PRP) for BB survival benefit in heart failure with reduced ejection fraction patients. …

… 5988 patients with class II–IV heart failure and an ejection fraction of more than 40% to
receive … outcome was a composite of cardiovascular death or hospitalization for heart failure. …

… heart failure (HF) have HF with preserved ejection fraction (… on cut-points in left ventricular
ejection fraction (LVEF), recent … efficacious in HF with reduced ejection fraction (HFrEF) have …

… Heart failure with preserved ejection fraction (HFpEF) is a … treatment of heart failure with
reduced ejection fraction (HFrEF)… , and spironolactone, have failed to improve outcomes in …