Estrogen receptors in colorectal cancer: Facts, novelties and perspectives

I Ditonno, G Losurdo, M Rendina, M Pricci, B Girardi… - Current …, 2021 - mdpi.com
… by treating HCT116 colon cancer cells with ERβ gene constructed into adenoviral vectors
alone or in combination with raloxifene, a selective estrogen receptor modulator. Only the …

Implications of estrogen and its receptors in colorectal carcinoma

PK Das, J Saha, S Pillai, AKY Lam, V Gopalan… - Cancer …, 2023 - Wiley Online Library
… In this review, we discuss the roles of estrogen receptors and their multiple molecular
targets in CRC pathogenesis. We also outlined the use of some potential natural or synthetic …

Targeting estrogen receptors in colorectal cancer

JW Maingi, S Tang, S Liu, W Ngenya, E Bao - Molecular Biology Reports, 2020 - Springer
… Abnormal estrogen receptor signaling may increase the risk of development of a variety
of … Estrogen receptor beta (ERβ) is the predominant subtype in the colonic epithelium and …

Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background

N Honma, T Arai, Y Matsuda, Y Fukunaga… - Journal of Cancer …, 2022 - Springer
… Representative estrogen receptor (ER)-β staining of cancerous … a A mucinous carcinoma of
the cecum in a 78 years/o … important estrogen receptor, G protein-coupled estrogen receptor (…

Therapeutic strategies and potential actions of female sex steroid hormones and their receptors in Colon cancer based on preclinical studies

AA Mahbub - Life, 2022 - mdpi.com
… actions are believed to be mediated through the ERβ, which is a predominant estrogen
receptor subtype in the colon [73,132]. The expression of ERβ is decreased during …

[HTML][HTML] Estrogen and progesterone expression in colorectal carcinoma: A clinicopathological study

AAEG Abd ElLateef, AES Mohamed… - Asian Pacific Journal …, 2020 - ncbi.nlm.nih.gov
Estrogen receptor beta (ERβ) is by far the predominant isoform in the colon mucosa (Campbell-Thompson
et al., 2001; Konstantinopoulos et al., 2003; Wong et al., 2005) and its …

Genome‐wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity

R Indukuri, MH Jafferali, D Song… - … journal of cancer, 2021 - Wiley Online Library
… Studies demonstrate that estrogen activating estrogen receptor beta (ERβ) protects against
CRC. ERβ is a nuclear receptor that regulates gene expression through interactions with the …

Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
estrogen receptor in the healthy colonic epithelium and the expression of ERβ1 is reduced in
tumor cells compared to normal colon (… with colon carcinoma (263). This protective effect of …

Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

H De Vitto, J Ryu, A Calderon-Aparicio, J Monts… - Cancer & …, 2020 - Springer
… The estrogen-related receptor family (ERRα, ERRβ, and ERRγ) was first described as an …
receptor family and was originally identified based on its homology to estrogen receptor alpha (…

Role of G protein-coupled estrogen receptor in digestive system carcinomas: a minireview

Y Qiu, J Xiong, T Yu - OncoTargets and therapy, 2021 - Taylor & Francis
… Digestive system carcinomas are one of the leading causes of cancer-related deaths
worldwide. G protein-coupled estrogen receptor (GPER), a novel estrogen receptor, has been …