Clinical predictors of response to EGFR-tyrosine kinase inhibitors in EGFR-mutated non-small cell lung cancer: a real-world multicentric cohort analysis from India
A Garg, U Batra, P Choudhary, D Jain… - Current Problems in …, 2020 - Elsevier
… EGFR-mutations in this study actually had poorer outcomes with gefitinib (hazard ratio for …
than erlotinib, further information is needed pertaining to osimertinib. Thirdly, our study has not …
than erlotinib, further information is needed pertaining to osimertinib. Thirdly, our study has not …
EGFR inhibitor erlotinib plus monoclonal antibody versus erlotinib alone for first-line treatment of advanced non-small cell lung carcinoma: A systematic review and …
M Liu, K Xiao, L Yang - International Immunopharmacology, 2023 - Elsevier
… All of these studies comprised independent cohorts (separate … Gefitinib monotherapy is also
widely used currently. In a phase III trial comparing erlotinib with gefitinib, the erlotinib group …
widely used currently. In a phase III trial comparing erlotinib with gefitinib, the erlotinib group …
Statins use and its impact in EGFR‐TKIs resistance to prolong the survival of lung cancer patients: A Cancer registry cohort study in Taiwan
… EGFR-TKI chemotherapy, that is gefitinib or erlotinib; data were censored at the date of … , or
the end of the study, ie December 31, 2013. We ascertained the study outcomes using HWDS …
the end of the study, ie December 31, 2013. We ascertained the study outcomes using HWDS …
[HTML][HTML] A phase II, multicenter, two cohort study of 160 mg osimertinib in EGFR T790M-positive non-small-cell lung cancer patients with brain metastases or …
… In this study, osimertinib 160 mg was also effective and safe. It showed a 62% ORR and
a … Thus, we conducted this phase II, prospective, two cohort study using a double dose of …
a … Thus, we conducted this phase II, prospective, two cohort study using a double dose of …
[HTML][HTML] Fatal toxic effects related to EGFR tyrosine kinase inhibitors based on 53 cohorts with 9,569 participants
X Xie, X Wang, S Wu, H Yang, J Liu… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
… Erlotinib was dominantly used, and first-generation EGFR-TKI composed of erlotinib and
gefitinib was frequently used in 53 cohorts. Detailed characteristics of 53 eligible cohorts were …
gefitinib was frequently used in 53 cohorts. Detailed characteristics of 53 eligible cohorts were …
[HTML][HTML] Apatinib plus gefitinib as first-line treatment in advanced EGFR-mutant NSCLC: the phase III ACTIVE study (CTONG1706)
H Zhao, W Yao, X Min, K Gu, G Yu, Z Zhang… - Journal of thoracic …, 2021 - Elsevier
… first-generation EGFR TKIs (eg, gefitinib and erlotinib) is approximately 10 to 12 months.10, …
, is a superior first-line therapy according to the FLAURA study, 11 , 12 there is no standard …
, is a superior first-line therapy according to the FLAURA study, 11 , 12 there is no standard …
Population pharmacokinetics of Erlotinib in patients with non–small cell Lung Cancer: its application for individualized dosing regimens in older patients
E Cardoso, M Guidi, N Khoudour… - Clinical …, 2020 - Elsevier
… This large cohort study confirms the substantial interindividual variability in erlotinib plasma
… This large variability in erlotinib pharmacokinetics indicates that the standard recommended …
… This large variability in erlotinib pharmacokinetics indicates that the standard recommended …
[HTML][HTML] Comparing survival and subsequent treatment of first-line tyrosine kinase inhibitors in patients of advanced lung adenocarcinoma with epidermal growth factor …
MY Huang, KP Hsieh, RY Huang, JY Hung… - Journal of the Formosan …, 2022 - Elsevier
… In this population-based retrospective cohort study, we … our study cohort, including 6230
(59.7%) receiving gefitinib, … ; the number of gefitinib users decreased after erlotinib and afatinib …
(59.7%) receiving gefitinib, … ; the number of gefitinib users decreased after erlotinib and afatinib …
… acquired resistance for EGFR-TKI plus thoracic SBRT in patients with advanced EGFR-mutant non–small-cell lung cancer: a propensity-matched retrospective study
X Wang, Z Zeng, J Cai, P Xu, P Liang, Y Luo, A Liu - BMC cancer, 2021 - Springer
… Forty-six patients with 64 lung lesions treated with at least 8 weeks of TKIs (erlotinib, gefitinib,
… Using PSM with a ratio of 1:2, the study cohort was composed of 45 patients treated with …
… Using PSM with a ratio of 1:2, the study cohort was composed of 45 patients treated with …
Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT …
… Despite the positive results of tepotinib plus gefitinib in patients with MET amplification as …
limitation of this study was the poor recruitment, resulting in early termination of the study with a …
limitation of this study was the poor recruitment, resulting in early termination of the study with a …