One ring to rule them all? Structural and functional diversity in the nuclear pore complex

J Fernandez-Martinez, MP Rout - Trends in biochemical sciences, 2021 - cell.com
… takes place) and the cytoplasm (where translation happens), eukaryotic cells have
developed a remarkable molecular machine, a massive protein complex called the nuclear pore

[HTML][HTML] Nuclear periphery takes center stage: the role of nuclear pore complexes in cell identity and aging

UH Cho, MW Hetzer - Neuron, 2020 - cell.com
gene regulation at the nuclear envelope. Like many other research topics in the field of biology,
NPC-mediated genome regulation … genome-wide screening for NPC-interacting genes ( …

Nuclear pores dilate and constrict in cellulo

CE Zimmerli, M Allegretti, V Rantos, SK Goetz… - Science, 2021 - science.org
… The nucleus of eukaryotic cells is enclosed by the nuclear envelope, a double membrane
punctuated with nuclear pore complexes (NPCs). These giant channels in the nuclear

Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes

LM Hoffman, MA Smith, CC Jensen… - Molecular biology of …, 2020 - Am Soc Cell Biol
… NPC-dependent cargo import and export, and that NPCs may influence gene regulation
via the functional nuclear organization, positioning active chromatin domains adjacent to …

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

S Kadota, J Ou, Y Shi, JT Lee, J Sun… - Nature …, 2020 - nature.com
… NUP153 mediates transcription regulation of developmental genesgene regulation in
pluripotent mouse ES cells. To define NUP153-mediated chromatin structure and gene regulation, …

Core components of the nuclear pore bind distinct states of chromatin and contribute to polycomb repression

A Gozalo, A Duke, Y Lan, P Pascual-Garcia… - Molecular Cell, 2020 - cell.com
… Interactions between the genome and the nuclear pore complex (NPC) have been
implicated in multiple gene regulatory processes, but the underlying logic of these interactions …

Cargo transport through the nuclear pore complex at a glance

G Paci, J Caria, EA Lemke - Journal of cell science, 2021 - journals.biologists.com
… envelope is a hallmark of eukaryotic cells, in which the genetic material is compartmentalized
inside the nucleus. The nuclear pore complex (NPC) is the major gateway to the nucleus

Nuclear pore complexes—a doorway to neural injury in neurodegeneration

AN Coyne, JD Rothstein - Nature Reviews Neurology, 2022 - nature.com
… The main subcomplexes of the nuclear pore complex are the cytoplasmic ring and filaments,
the outer ring, the inner ring, the transmembrane ring, the central channel and the nuclear

A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
… relevant to gene regulation and discuss their assembly, internal structure, gene-regulatory
roles … P granules localized on the nuclear membrane are thought to trap in the nuclear pores

Architecture of the cytoplasmic face of the nuclear pore

CJ Bley, S Nie, GW Mobbs, S Petrovic, AT Gres, X Liu… - Science, 2022 - science.org
… Embedded in nuclear envelope pores, which are generated by the circumscribed fusion
of the inner and outer nuclear membranes, nuclear pore complexes (NPCs) are the sole …