One ring to rule them all? Structural and functional diversity in the nuclear pore complex
J Fernandez-Martinez, MP Rout - Trends in biochemical sciences, 2021 - cell.com
… takes place) and the cytoplasm (where translation happens), eukaryotic cells have
developed a remarkable molecular machine, a massive protein complex called the nuclear pore …
developed a remarkable molecular machine, a massive protein complex called the nuclear pore …
[HTML][HTML] Nuclear periphery takes center stage: the role of nuclear pore complexes in cell identity and aging
UH Cho, MW Hetzer - Neuron, 2020 - cell.com
… gene regulation at the nuclear envelope. Like many other research topics in the field of biology,
NPC-mediated genome regulation … genome-wide screening for NPC-interacting genes ( …
NPC-mediated genome regulation … genome-wide screening for NPC-interacting genes ( …
Nuclear pores dilate and constrict in cellulo
CE Zimmerli, M Allegretti, V Rantos, SK Goetz… - Science, 2021 - science.org
… The nucleus of eukaryotic cells is enclosed by the nuclear envelope, a double membrane
punctuated with nuclear pore complexes (NPCs). These giant channels in the nuclear …
punctuated with nuclear pore complexes (NPCs). These giant channels in the nuclear …
Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes
LM Hoffman, MA Smith, CC Jensen… - Molecular biology of …, 2020 - Am Soc Cell Biol
… NPC-dependent cargo import and export, and that NPCs may influence gene regulation
via the functional nuclear organization, positioning active chromatin domains adjacent to …
via the functional nuclear organization, positioning active chromatin domains adjacent to …
Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
S Kadota, J Ou, Y Shi, JT Lee, J Sun… - Nature …, 2020 - nature.com
… NUP153 mediates transcription regulation of developmental genes … gene regulation in
pluripotent mouse ES cells. To define NUP153-mediated chromatin structure and gene regulation, …
pluripotent mouse ES cells. To define NUP153-mediated chromatin structure and gene regulation, …
Core components of the nuclear pore bind distinct states of chromatin and contribute to polycomb repression
A Gozalo, A Duke, Y Lan, P Pascual-Garcia… - Molecular Cell, 2020 - cell.com
… Interactions between the genome and the nuclear pore complex (NPC) have been
implicated in multiple gene regulatory processes, but the underlying logic of these interactions …
implicated in multiple gene regulatory processes, but the underlying logic of these interactions …
Cargo transport through the nuclear pore complex at a glance
… envelope is a hallmark of eukaryotic cells, in which the genetic material is compartmentalized
inside the nucleus. The nuclear pore complex (NPC) is the major gateway to the nucleus …
inside the nucleus. The nuclear pore complex (NPC) is the major gateway to the nucleus …
Nuclear pore complexes—a doorway to neural injury in neurodegeneration
AN Coyne, JD Rothstein - Nature Reviews Neurology, 2022 - nature.com
… The main subcomplexes of the nuclear pore complex are the cytoplasmic ring and filaments,
the outer ring, the inner ring, the transmembrane ring, the central channel and the nuclear …
the outer ring, the inner ring, the transmembrane ring, the central channel and the nuclear …
A guide to membraneless organelles and their various roles in gene regulation
T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
… relevant to gene regulation and discuss their assembly, internal structure, gene-regulatory
roles … P granules localized on the nuclear membrane are thought to trap in the nuclear pores …
roles … P granules localized on the nuclear membrane are thought to trap in the nuclear pores …
Architecture of the cytoplasmic face of the nuclear pore
… Embedded in nuclear envelope pores, which are generated by the circumscribed fusion
of the inner and outer nuclear membranes, nuclear pore complexes (NPCs) are the sole …
of the inner and outer nuclear membranes, nuclear pore complexes (NPCs) are the sole …