… loci in patients with Crohn disease (CD). Interestingly, c.2722G>C and c.… in genetic
susceptibility factors. While the NOD2 gene variants are significantly associated with the genetic risk …

… in the cause of Crohn’s disease, including a dysregulated immune system, an altered
microbiota, genetic susceptibility and environmental factors, but the cause of the disease remains …

… inflammatory bowel diseases, especially Crohn's disease, has increased remarkably. Crohn's
disease is assumed to be the result of a complex interplay between genetic susceptibility, …

… IBD GWAS hits, as well as previous rare-variant discoveries (Methods). We identified five
coding variants in genes not previously implicated in IBD… variants in genes previously known to …

… predict IBD disease course. Genome-wide association studies [GWAS] have identified
around 240 independent genetic susceptibility loci for IBD and have implicated genes … of IBD. …

… associated with Crohns disease (CD), however, as with all complex diseases, … susceptibility
genes as well as ten genes where coding variation directly implicates the gene in disease …

… analysed diseases and all of them showed a significant effect on gene … genetic risk loci. In
conclusion, through the first cross-disease meta-analysis of SSc and CD, we identified genetic …

… Inflammatory bowel disease (IBD) is a complex multifactorial disorder in which external and
… in genetically susceptible individuals. Crohn’s disease (CD), one of the two types of IBD, is …

… gene that was demonstrated to be associated with IBD, specifically in CD [7]. However, this
gene accounts for only a portion of the overall genetic … hundreds of candidate genes for IBD [8…

… Ultimately, IBD seems to emanate from an uncontrollably continuous inflammatory process …
microbiome in a genetically susceptible individual. It is a multifactorial disease stemming from …