… metabolized by hydrolase activity and forms an intermediate metabolite, GS-704277, which
then is subject … phosphorylated to the pharmacologically active nucleoside triphosphate, GS-…

… the total amount of conjugated metabolites. A large proportion of … Psilocin, the active metabolite
of psilocybin, was metabolized … The increase in metabolite concentrations over time was …

… studies, a phase I study was conducted in healthy volunteers (HVs) to evaluate the … of
the PK and PD of cemdisiran and its major active metabolite AS(N-2)3′-cemdisiran, and …

… active metabolites, whereas in case of selatogrel it is the parent compound that triggers
IPA. Metabolite profiling data indicated the glucuronide M21 as most abundant metabolite in …

… essential AAs as well as vitamins, metabolites and lipids commonly found in human sweat
(… human trials by enroling both healthy subjects and patients towards personalized monitoring …

… In contrast, renal impairment was expected to affect only the PK of the inactive metabolite of
remimazolam, but not the PK or PD of remimazolam itself, which in healthy subjects is found …

… As 7-OH-CBD is an active metabolite and 7-COOH-CBD is highly abundant,11 understanding
changes in the MR with reference to extrinsic factors such as food is important. Although …

… and adenoma patients compared with healthy subjects. Aminoacyl-tRNA biosynthesis needs
… in this study compared to CRA and healthy subjects. They are essential nutrients for cancer …

… to analyze the structure and diversity of the intestinal flora and metabolites of the gut
microbiota in RA patients compared with healthy subjects. In this study, α-diversity analysis of the …

… , and the impact of HSK3486-related metabolites on pharmacokinetics and pharmacology,
we conducted a study in healthy Chinese subjects to clarify the distribution, metabolism and …