[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
… and possibly immune diseases.23 Support for this and further new insight derived from …
have been found to affect the host immune response, providing an experimental system for …

B cell depletion therapies in autoimmune disease: advances and mechanistic insights

DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
Immune responses to antigens occur within secondary lymphoid organs (lymph nodes,
tonsils and spleen): the spleen supports immune responses to blood-borne antigens, whereas …

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
immune cell infiltration, leading to CNS inflammation and neuron death, 93 it remains
unclear whether the peripheral immune response is the cause or a result of CNS pathology. …

Constitutive immune mechanisms: mediators of host defence and immune regulation

SR Paludan, T Pradeu, SL Masters… - Nature Reviews …, 2021 - nature.com
… or potentially disruptive immune responses. In addition, vigorous immune responses are not
… RNAi is another constitutive immune mechanism that directly controls viral replication. RNAi …

Mechanistic insights into the oxidized low‐density lipoprotein‐induced atherosclerosis

C Khatana, NK Saini, S Chakrabarti… - Oxidative medicine …, 2020 - Wiley Online Library
… The underlying mechanism is very well elucidated in literature … We shall brief the Ox-LDL-induced
atherogenic mechanismmechanistic insights for therapeutic interventions [124, 125]. …

Autophagy and ALS: mechanistic insights and therapeutic implications

JP Chua, H De Calbiac, E Kabashi, SJ Barmada - Autophagy, 2022 - Taylor & Francis
… accumulation and a hyperactive immune response characterized by enhanced
production … the significance of C9orf72 in maintaining physiological immune responses [Citation440]. …

Modulation of immune responses by particle size and shape

MV Baranov, M Kumar, S Sacanna… - Frontiers in …, 2021 - frontiersin.org
… and subsequent immune responses, particularly inflammasome activation and T cell activation.
Understanding how the physical properties of particles affect immune responses can aid …

Strategies Employed to Evade the Host Immune Response and the Mechanism of Drug Resistance in Mycobacterium tuberculosis: In Search of Finding New Targets

BA Sheikh, BA Bhat, Z Ahmad… - Current pharmaceutical …, 2022 - benthamdirect.com
… Abstract: The partial effectiveness of the host immune response to M. tuberculosis drives …
correlates of immunity of M. tuberculosis infection or why there is a significant immunity failure to …

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

C Li, A Lee, L Grigoryan, PS Arunachalam… - Nature …, 2022 - nature.com
… The current study, involving a detailed analysis of immune responses to vaccination of
mice with the BNT162b2 vaccine, provided several new mechanistic insights (Fig. 8). As is the …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
… system in COVID-19, a deeper understanding of the mechanism behind the immune
dysregulation might give us clues for the clinical management of the severe cases and for …