The Role of Iron in Staphylococcus aureus Infection and Human Disease: A Metal Tug of War at the Host—Microbe Interface

MC van Dijk, RM de Kruijff… - Frontiers in cell and …, 2022 - frontiersin.org
Iron deficiency anemia can be treated with oral or … of Fe by the opportunistic pathogen
Staphylococcus aureus. Ferric uptake … for heme iron as an Fe source, which is enabled by the Iron-…

Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus hemB Small-Colony Variant

IZ Batko, RS Flannagan… - Journal of …, 2021 - Am Soc Microbiol
… valuable insights into the iron acquisition strategies employed by S. aureus SCVs and
indicate that perturbation of hemin utilization could render SCVs unable to grow under iron-limited …

Staphylococcus aureus Biofilms and Their Response to a Relevant in vivo Iron Source

P Dauros-Singorenko, S Wiles, S Swift - Frontiers in Microbiology, 2020 - frontiersin.org
Iron restriction by the host is a stimulus for biofilm formation for some Staphylococcus aureus
isolates… scenarios bacteria are exposed to abundant amounts of hemoglobin (Hb), which S. …

In vivo growth of Staphylococcus lugdunensis is facilitated by the concerted function of heme and non-heme iron acquisition mechanisms

…, B Kumar, LA Adolf, JJ Power, S Heilbronner… - Journal of Biological …, 2022 - ASBMB
… lugdunensis can usurp hydroxamate siderophores and staphyloferrin A and B from
Staphylococcus aureus. These transport activities all required a functional FhuC ATPase. Moreover, …

Iron Acquisition by Bacterial Pathogens: Beyond tris‐Catecholate Complexes

Y Zhang, S Sen, DP Giedroc - ChemBioChem, 2020 - Wiley Online Library
… , SstD, is found in Staphylococcus aureus and has been shown to be required for Ent-dependent
Fe III acquisition and catecholamine-stimulated growth under severely iron-restricted …

The Key Element Role of Metallophores in the Pathogenicity and Virulence of Staphylococcus aureus: A Review

G Ghssein, Z Ezzeddine - Biology, 2022 - mdpi.com
… (iron chelating molecules) and staphylopine (wide- spectrum metallophore) are secreted by
Staphylococcus aureus … reduce iron bound to transferrin thus forming iron complexes that S. …

Heme protects Pseudomonas aeruginosa and Staphylococcus aureus from calprotectin-induced iron starvation

EM Zygiel, AO Obisesan, CE Nelson… - Journal of Biological …, 2021 - ASBMB
… Pseudomonas aeruginosa and Staphylococcus aureus are opportunistic bacterial pathogens
that cause severe infections in immunocompromised individuals and patients with cystic …

Siderophore-Mediated Iron Acquisition Plays a Critical Role in Biofilm Formation and Survival of Staphylococcus epidermidis Within the Host

…, AM Silva, C Soares, S Morais, S Weißelberg… - Frontiers in …, 2021 - frontiersin.org
… Being a major cause of bloodstream infections originating from indwelling medical device
contamination (34), we hypothesized that siderophore-mediated iron acquisition provides S. …

Genetic regulation of metal ion homeostasis in Staphylococcus aureus

EE Price, JM Boyd - Trends in microbiology, 2020 - cell.com
… In Staphylococcus aureus, the use of metal ion cofactors is required in a diverse array of …
of functioning with iron or manganese promotes the resistance of Staphylococcus aureus to …

Characterization of an Antibacterial Agent Targeting Ferrous Iron Transport Protein FeoB against Staphylococcus aureus and Gram-Positive Bacteria

M Shin, Y Jin, J Park, D Mun, SR Kim… - ACS Chemical …, 2020 - ACS Publications
… -resistant Staphylococcus aureus strains has become a serious clinical problem. Iron is …
homeostasis, (17) and cellular metabolism associated with iron acquisition is more active …