[HTML][HTML] p38 MAPK pathway in the heart: new insights in health and disease

R Romero-Becerra, AM Santamans… - International Journal of …, 2020 - mdpi.com
… activated p38 family member. However, understanding remains limited of how the different
p38 … In this review, we summarize current knowledge of p38 function in the heart and discuss …

Redox regulation of cardiac ASK1 (apoptosis signal-regulating kinase 1) controls p38-MAPK (mitogen-activated protein kinase) and orchestrates cardiac remodeling …

DN Meijles, JJ Cull, T Markou, STE Cooper… - …, 2020 - Am Heart Assoc
p38-MAPKs and JNKs, we first clarified and delineated the ASK1 signaling pathway in the
heart… levels of redox stress, signaling selectively to p38-MAPK (not JNKs). ASK1, therefore, …

[HTML][HTML] Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy associated with p38 signalling and TLR4/JAK/STAT3 pathway

Y Li, WW Zhou, JH Sun, HX Yang, GR Xu… - Biomedicine & …, 2021 - Elsevier
p38 MAPK also contributes to cardiac hypertrophy induced by pressure overload [12]. A
recent report showed that p38 MAPK … In this study, the size and weight of rat hearts were …

[PDF][PDF] Protective effect of MAPK signaling pathway mediated by ITGB3 gene silencing on myocardial ischemia-reperfusion injury in mice and its mechanism.

MC Wang, D Wang, YH Lu, ZH Li… - European Review for …, 2021 - europeanreview.org
… (MAPK) signaling pathway is recognized to play a role in myocardial protection16. p38 is one
of the most important members of MAPK … bottom of the heart, the long axis of the heart was …

Urantide attenuates myocardial damage in atherosclerotic rats by regulating the MAPK signalling pathway

J Zhao, G Miao, T Wang, J Li, L Xie - Life Sciences, 2020 - Elsevier
… to detect the levels of p-P38, p-ERK and p-JNK in the heart tissue from the rats in each group…
pathway and the P38 MAPK pathway [28,29]. These three MAPK signalling pathways are …

[HTML][HTML] Elevating miR-378 strengthens the isoflurane-mediated effects on myocardial ischemia-reperfusion injury in mice via suppression of MAPK1

R Zhou, Y Jia, Y Wang, Z Li, J Qi… - American Journal of …, 2021 - ncbi.nlm.nih.gov
… In fact, ISO can repress p38 MAPK activity during MI/RI and phosphorylated p38 MAPK in
microglial … It suits well with that ISO can, through repressing the p38 MAPK signaling pathway, …

p38-MAPK and JAK/STAT Pathway Inhibition Reduces Indoxyl Sulfate-Induced Impairment of Human Endothelial Cells

C Thomas, D Couch, B Wang - Heart, Lung and Circulation, 2022 - heartlungcirc.org
p38-MAPK and JAK-STAT pathways appear to play an important pathological role in IS-…
IS stimulated the phosphorylation of NFkB, p38MAPK, STAT1 and STAT3 (p,0.05). VCP-979 …

[HTML][HTML] Paeoniflorin improves myocardial injury via p38 MAPK/NF-KB p65 inhibition in lipopolysaccharide-induced mouse

S Wang, D Jia, H Lu, X Qu - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
… Pae might be as a new drug candidate for myocardial ischaemic complications… MAPK)
signaling plays an important role in body inflammation, and that sustained activation of p38 MAPK

[HTML][HTML] Polygonum orientale L. Alleviates Myocardial Ischemia-Induced Injury via Activation of MAPK/ERK Signaling Pathway

C Fu, M Wang, Y Lu, J Pan, Y Li, Y Li, Y Wang, A Wang… - Molecules, 2023 - mdpi.com
MAPK/ERK signaling pathway. It was found that PO could reduce the elevation of the ST
segment; injury of heart … kinase (JNK) and p38 are the members of MAPK signaling pathways [10…

[HTML][HTML] Sevoflurane pre-conditioning ameliorates diabetic myocardial ischemia/reperfusion injury via differential regulation of p38 and ERK

D Xie, J Zhao, R Guo, L Jiao, Y Zhang, WB Lau… - Scientific Reports, 2020 - nature.com
… the heart via AMPK-dependent inhibition of pro-death MAPK in … Role of p38-mitogen-activated
protein kinase in ischaemic … Acute adenosine preconditioning is mediated by p38 MAPK