… were associated with genomic aberrations that were associated with the RAS/RTK pathway
79 . … Selective inhibitors targeting specific KRAS mutations are urgently needed to effectively …

… effect of RTK inhibition may be … inhibition could be effective in patients with KRAS mutant
lung tumors [[114]]. Interestingly, CDK4/6 inhibitors also synergized with KRAS G12C inhibitors …

… upstream signaling with RTK inhibitors that increase the activity of KRAS G12C … RTK
signaling to KRAS. Accordingly, SHP2 inhibitors are active in cancers driven by KRAS mutations …

… inhibitors that block mutant KRAS G12C were successfully developed and sotorasib was the
first KRAS G12C inhibitor to … We also discuss the relationship between KRAS mutations and …

… with KRAS Q61 and/or PIK3CA mutations were … KRAS mutant cell lines in both PIK3CA-mutated
and PIK3CA wild-type cancers. Our findings demonstrate that vertical inhibition of RTK/…

… Here, we found that GRB7 maintained RTK signaling via PLK1 in CRC cells with KRAS
mutations. GRB7 overexpression promoted the cytoplasmic localization of PLK1, which might be …

… survival in KRAS mutant cancer cells, (… inhibitor of proximal RTK signaling may be a common
therapeutic strategy to enhance RTK inhibitor efficacy and treat cancers dependent on RTK …

… lung cancer, EMT has been shown to play a defining role in the feedback reactivation of
RTK signaling following MEK inhibition. In epithelial-like cells, this feedback was mediated by …

… KRAS mutations favor the active form with inhibition of GTPAse activity. KRAS mutations are
… by a release of upstream feedback inhibition of RTK which bypass KRAS G12C inhibition by …

… KRAS mutations impart insensitivity to inhibitors of upstream … mutations within KRAS and
associated RTK and MAPK signaling molecules, acquired resistance to KRAS G12C inhibitors …